Protein Info for BWI76_RS05640 in Klebsiella michiganensis M5al

Annotation: GntR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 258 PF00392: GntR" amino acids 10 to 73 (64 residues), 80.9 bits, see alignment E=4.1e-27 PF07729: FCD" amino acids 98 to 226 (129 residues), 80.3 bits, see alignment E=1.7e-26

Best Hits

Swiss-Prot: 88% identical to UXUR_ECOLI: Uxu operon transcriptional regulator (uxuR) from Escherichia coli (strain K12)

KEGG orthology group: K13637, GntR family transcriptional regulator, uxuAB operon transcriptional repressor (inferred from 90% identity to sed:SeD_A4908)

Predicted SEED Role

"Uxu operon transcriptional regulator" in subsystem D-Galacturonate and D-Glucuronate Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AZ68 at UniProt or InterPro

Protein Sequence (258 amino acids)

>BWI76_RS05640 GntR family transcriptional regulator (Klebsiella michiganensis M5al)
MKSQTSQHRPYQEVGALIRDLIVKTPYRPGDRLPPEREIAEMLDVTRTVVREALIMLEIK
GLVEVRRGAGIYVLDNAAGEGAAESADMNHCNDAGPFELLQARQLLESNIAEFAALQATR
EDIIKMRQALQLEERELASSAPGGSESGDMQFHLAIAEATHNSMLVELFRQSWQWRENNP
MWIQLHRHLGDTHYRQDWLVDHKRILAALIKKDARAAKLAMWQHLENVKRRLLEFSNVDD
IYFDGYLFDSWPLDNADA