Protein Info for BWI76_RS05620 in Klebsiella michiganensis M5al

Annotation: NAD-dependent succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 19 to 477 (459 residues), 588.8 bits, E=3.3e-181
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 30 to 476 (447 residues), 791.5 bits, E=1.1e-242

Best Hits

Swiss-Prot: 89% identical to GABD_ECOLI: Succinate-semialdehyde dehydrogenase [NADP(+)] GabD (gabD) from Escherichia coli (strain K12)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 90% identity to kpe:KPK_4476)

MetaCyc: 89% identical to succinate-semialdehyde dehydrogenase (NADP+) GabD (Escherichia coli K-12 substr. MG1655)
SUCCSEMIALDDEHYDROG-RXN [EC: 1.2.1.79]; Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.79, 1.2.1.20]

Predicted SEED Role

No annotation

MetaCyc Pathways

• superpathway of L-arginine and L-ornithine degradation (13/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (11/11 steps found)
• superpathway of 4-aminobutanoate degradation (3/3 steps found)
• L-lysine degradation X (5/6 steps found)
• 4-aminobutanoate degradation II (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• TCA cycle IV (2-oxoglutarate decarboxylase) (7/9 steps found)
• 4-hydroxyphenylacetate degradation (6/8 steps found)
• L-lysine degradation I (5/7 steps found)
• L-lysine degradation IV (2/5 steps found)
• L-lysine degradation III (2/6 steps found)
• nicotine degradation II (pyrrolidine pathway) (2/11 steps found)
• nicotine degradation I (pyridine pathway) (6/17 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20 or 1.2.1.79

Sequence Analysis Tools

See A0A285AZ09 at UniProt or InterPro

Protein Sequence (482 amino acids)

>BWI76_RS05620 NAD-dependent succinate-semialdehyde dehydrogenase (Klebsiella michiganensis M5al)
MQLNDPTLFRQQAMINGRWRDASGKETLAVTNPANGQPLGNVPKMGAGETREAIDAAARA
LPAWRALTAKERSSILRRWFELMMEHQDDLARLMTLEQGKPLAEAKGEISYAASFIEWFA
EEGKRIYGDTIPGHQADKRLLVIKQPIGVTAAITPWNFPSAMITRKAGPALAAGCTMVLK
PASQTPFSALALAELANRAGIPEGVFNVVTGSASEVGGELTGNPLVRKLSFTGSTEIGRQ
LMEQCAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDS
VYDRFAEKLQQAVSKLQIGDGLQPNVTIGPLIDEKAIAKVQEHIADALGKGARVVTGGKA
HELGGNFFQPTILVDVPGDAKVAKEETFGPLAPLFRFKDEADVIAQANDTEFGLAAYFYA
RDLGRVFRVGEALEYGIIGINTGLISTEVAPFGGVKSSGLGREGSKYGIEDYLEIKYMCI
GI