Protein Info for BWI76_RS05290 in Klebsiella michiganensis M5al

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1160 TIGR00594: DNA polymerase III, alpha subunit" amino acids 6 to 1031 (1026 residues), 1445.4 bits, see alignment E=0 PF02811: PHP" amino acids 8 to 172 (165 residues), 137.6 bits, see alignment E=1.5e-43 PF07733: DNA_pol3_alpha" amino acids 291 to 558 (268 residues), 353.9 bits, see alignment E=1.8e-109 PF17657: DNA_pol3_finger" amino acids 561 to 735 (175 residues), 221.9 bits, see alignment E=9.9e-70 PF14579: HHH_6" amino acids 808 to 898 (91 residues), 96 bits, see alignment 3.7e-31 PF01336: tRNA_anti-codon" amino acids 1000 to 1072 (73 residues), 43.3 bits, see alignment 8.8e-15 PF20914: DNA_pol_IIIA_C" amino acids 1100 to 1151 (52 residues), 98.3 bits, see alignment (E = 5.2e-32)

Best Hits

Swiss-Prot: 96% identical to DPO3A_SALTY: DNA polymerase III subunit alpha (dnaE) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 77% identity to avr:B565_3040)

MetaCyc: 95% identical to DNA polymerase III subunit alpha (Escherichia coli K-12 substr. MG1655)
DNA-directed DNA polymerase. [EC: 2.7.7.7]

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AYV9 at UniProt or InterPro

Protein Sequence (1160 amino acids)

>BWI76_RS05290 DNA polymerase III subunit alpha (Klebsiella michiganensis M5al)
MAEPRFVHLRVHSDYSMIDGLAKTGPLVKKAAALGMPALAITDFTNLCGLVKFYGAGHGA
GIKPIVGADFHVQSDLLGDELSQLTVLAANNAGYQNLTLLISKAYQRGYGAAGPIIDRDW
LIELKEGLILLSGGRMGDVGRSLLRGNMALVDQCVDFYEQHFPDCYFLELIRTGRQDEEP
YLHAAVGLAETRGLPVVATNDVRFLEPGDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYM
RSEEEMCELFSDIPEALQNTVEIAKRCNVTVRLGEYFLPQFPTGDMTTEDYLVKKSKEGL
EERLEFLFPDPDERTKRRPEYDERLDIELQVINQMGFPGYFLIVMEFIQWSKDNGVPVGP
GRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPDFDVDFCMEKRDQVIEHVAD
MYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLAKAFEAEPQ
LPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDEAGQHPVTQ
FDKNDVEYAGLVKFDFLGLRTLTIINWALEMINARREKNGEGPLDIAAIPLDDKKSFDML
QRSETTAVFQLESRGMKDLIKRLQPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREE
ISYPDVQWQHECLKPVLEPTYGIILYQEQVMQIAQELSGYTLGGADMLRRAMGKKKPEEM
AKQRGTFEEGARKRGVDGELAIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPA
EFMAAVMTADMDNTEKVVGLVDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKG
VGEGPIEAIIEARNQGGYFRELFDLCARTDIKKLNRRVLEKLIMSGAFDRLGPHRAALMN
SLGDALKAADQHAKAEAIGQADMFGVLAEEPEQIEQSYANCQPWPEQVVLDGERETLGLY
LTGHPINQYLKEIERYVGGVRLKDMHPTDRGKVTTAAGLVIAARVMVTKRGNRIGICTLD
DRSGRLEVMLFTDALDKYQQLLEKDRILIVSGQVSFDDFSGGLKMTAREVMDIDEAREKY
ARGLAISLTDRQIDDQLLNRLRQSLEPHRSGTIPVHLYYQRADARARLRFGATWRVSPSD
RLLNDLRGLIGSEQVELEFD