Protein Info for BWI76_RS05230 in Klebsiella michiganensis M5al

Annotation: 1-deoxy-D-xylulose-5-phosphate reductoisomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00243: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • amino acids 1 to 389 (389 residues), 603.7 bits, E=6.7e-186
• PF02670: DXP_reductoisom
  • amino acids 4 to 132 (129 residues), 168.7 bits, E=1.5e-53
• PF08436: DXP_redisom_C
  • amino acids 146 to 239 (94 residues), 123.1 bits, E=6.5e-40
• PF13288: DXPR_C
  • amino acids 271 to 386 (116 residues), 134.3 bits, E=3.6e-43

Best Hits

Swiss-Prot: 82% identical to DXR_ECO57: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 89% identity to eae:EAE_11660)

MetaCyc: 82% identical to 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli K-12 substr. MG1655)
1-deoxy-D-xylulose-5-phosphate reductoisomerase. [EC: 1.1.1.267]

Predicted SEED Role

"1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267)" in subsystem Isoprenoid Biosynthesis or polyprenyl synthesis (EC 1.1.1.267)

MetaCyc Pathways

• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (12/12 steps found)
• taxadiene biosynthesis (engineered) (12/13 steps found)
• methylerythritol phosphate pathway I (9/9 steps found)
• methylerythritol phosphate pathway II (9/9 steps found)
• isoprene biosynthesis I (9/10 steps found)
• superpathway of ergosterol biosynthesis II (11/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.267

Sequence Analysis Tools

See A0A285AYU1 at UniProt or InterPro

Protein Sequence (399 amino acids)

>BWI76_RS05230 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Klebsiella michiganensis M5al)
MKQLTILGSTGSIGCSTLDVVRHNPDSFSITALVAGKNVDRMVEQCLEFSPRYAVMDDAH
SAELLRAKLREQGSRTEVMSGQQAAAEVAALDEVEQVMAAIVGAAGLVPTLAAIRAGKTV
LLANKESLVTCGRLFMEAVQQYGARLLPVDSEHNAIFQSMPEPIQHNLGYADLTQNGVAS
ILLTGSGGPFRETAISELAAMTPDRACKHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASAEQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMGWPKRLNSGVKPLDFC
QLSHLSFSAPDYGRYPCLKLAMEAFDVGQAATTTLNAANEVSVAAFLNGDIRFTDIAAIN
QSVLDLQALNEPQSIDEVLAIDAMARVSAGQLLAARRKF