Protein Info for BWI76_RS04930 in Klebsiella michiganensis M5al

Annotation: FKBP-type peptidyl-prolyl cis-trans isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 569 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details PF01346: FKBP_N" amino acids 363 to 454 (92 residues), 39.1 bits, see alignment E=1.2e-13 PF00254: FKBP_C" amino acids 471 to 555 (85 residues), 30.4 bits, see alignment E=4e-11

Best Hits

Predicted SEED Role

"FKBP-type peptidyl-prolyl cis-trans isomerase FkpA precursor (EC 5.2.1.8)" in subsystem Peptidyl-prolyl cis-trans isomerase or Potassium homeostasis (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AYR5 at UniProt or InterPro

Protein Sequence (569 amino acids)

>BWI76_RS04930 FKBP-type peptidyl-prolyl cis-trans isomerase (Klebsiella michiganensis M5al)
MNGKIAKNFNSVSLAAVFVLALSPDAFAEKDALISVTTSSSSDASGPAFLNYAKEQQAQE
SREPVKPVEEKSNKTKTTNKKSVQSTNDISRQAAIISQKDKLIRQLRQQLEAKPVTINAA
ADNQKELTDKIQLLEKKLAAAVAEKQRLIDKELTAAAEIKQSVGQRNASENKIVQQEKRL
LLVESAKQKAELQLTEATAEKQALIKKLAAAETEKQDTASRLTAAASDKQALISKLAAAE
SAQGQMRAKLTAADAARQALQTKLEAAETDHKVVLAKLAAYETKEKDLTTKLAAAGVEKQ
ALTAKLDSFIISKQQSSLQEDAADKDKAQLQASADEITRLKTMLADAEAKKPAAIDLAKA
PLQQAYAIGVSMGAEVLQLLSTRDSQGVKMSKDTVLQGIQDSFSGNIALDEKARNKALFD
VSKKVFQNLKKIEQQTLSEGKKYQQKFAQQKGVVLKDGVYSRIDYAGKGKILDSDIVTVT
IKETLTDGTVINDMEAEGKVWSQSLKSYPPLFLGPIKRLGNHGAITVVIPPELAYGSEGK
PPKIPPGATMVYSLRIVDATAAQPQAKKP