Protein Info for BWI76_RS04455 in Klebsiella michiganensis M5al

Annotation: triphosphoribosyl-dephospho-CoA synthase CitG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 302 TIGR03125: triphosphoribosyl-dephospho-CoA synthase CitG" amino acids 21 to 292 (272 residues), 348.9 bits, see alignment E=1.1e-108 PF01874: CitG" amino acids 26 to 291 (266 residues), 262.3 bits, see alignment E=3.2e-82

Best Hits

Swiss-Prot: 83% identical to CITG_KLEPN: 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (citG) from Klebsiella pneumoniae

KEGG orthology group: None (inferred from 83% identity to eae:EAE_10965)

MetaCyc: 51% identical to triphosphoribosyl-dephospho-CoA synthase (Escherichia coli K-12 substr. MG1655)
2.7.8.25-RXN [EC: 2.4.2.52]

Predicted SEED Role

"2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (EC 2.7.8.25)" (EC 2.7.8.25)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.52, 2.7.8.25

Use Curated BLAST to search for 2.4.2.52 or 2.7.8.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AYD3 at UniProt or InterPro

Protein Sequence (302 amino acids)

>BWI76_RS04455 triphosphoribosyl-dephospho-CoA synthase CitG (Klebsiella michiganensis M5al)
MSEVMMSQHRPSSRQTVAAEEMVSRVERALLTEVRLTPKPGLVDIRNAGAHRDMDLASFE
ASTAVVAPWMEKFFIMGHDTANIMPEKVLTMLRPVGMACETDMLAATGGVNTHRGAIFAF
GLLSAAVGRLVARGEPVEQHRVCDQVARFCRGLVGRELSSAAGKKVSKGEGHFLRYGLSG
ARGEAESGFRTVRTQAMPVFNRVMAETGDTNLALLQTLLHLMAWNDDTNLVSRGGLEGLN
FVQQQAQRLLWEGGVLTDGGLEALRQLDDELIVRHLSPGGSADLLAVTSFLSGFPAGELF
LH