Protein Info for BWI76_RS04190 in Klebsiella michiganensis M5al

Annotation: Trp operon repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 110 TIGR01321: trp operon repressor" amino acids 12 to 104 (93 residues), 128.7 bits, see alignment E=4.3e-42 PF01371: Trp_repressor" amino acids 17 to 103 (87 residues), 96.2 bits, see alignment E=5.2e-32

Best Hits

Swiss-Prot: 94% identical to TRPR_KLEP3: Trp operon repressor (trpR) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: K03720, TrpR family transcriptional regulator, trp operon repressor (inferred from 92% identity to cro:ROD_50801)

Predicted SEED Role

"Transcriptional repressor protein TrpR" in subsystem Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AYB6 at UniProt or InterPro

Protein Sequence (110 amino acids)

>BWI76_RS04190 Trp operon repressor (Klebsiella michiganensis M5al)
MTQQSPYSAAVAEQRHQEWLRFVALLQQAYADDLHLPLLQLMLTPDEREALGTRVRIIEE
LLRGEMSQRELKNELGAGIATITRGSNSLKSAPAELRLWLEQALIKADDK