Protein Info for BWI76_RS04045 in Klebsiella michiganensis M5al

Annotation: PTS system lactose/cellobiose-specific transporter subunit IIC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 447 transmembrane" amino acids 38 to 58 (21 residues), see Phobius details amino acids 84 to 106 (23 residues), see Phobius details amino acids 116 to 134 (19 residues), see Phobius details amino acids 146 to 168 (23 residues), see Phobius details amino acids 189 to 209 (21 residues), see Phobius details amino acids 216 to 242 (27 residues), see Phobius details amino acids 247 to 267 (21 residues), see Phobius details amino acids 291 to 313 (23 residues), see Phobius details amino acids 325 to 345 (21 residues), see Phobius details amino acids 350 to 369 (20 residues), see Phobius details amino acids 375 to 396 (22 residues), see Phobius details amino acids 402 to 421 (20 residues), see Phobius details TIGR00410: PTS system, lactose/cellobiose family IIC component" amino acids 20 to 434 (415 residues), 372.6 bits, see alignment E=1.5e-115 PF02378: PTS_EIIC" amino acids 36 to 359 (324 residues), 201.2 bits, see alignment E=1.2e-63

Best Hits

KEGG orthology group: K02761, PTS system, cellobiose-specific IIC component (inferred from 96% identity to kva:Kvar_4427)

Predicted SEED Role

"PTS system, cellobiose-specific IIC component (EC 2.7.1.69)" in subsystem Beta-Glucoside Metabolism (EC 2.7.1.69)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AYA0 at UniProt or InterPro

Protein Sequence (447 amino acids)

>BWI76_RS04045 PTS system lactose/cellobiose-specific transporter subunit IIC (Klebsiella michiganensis M5al)
MSANHAAFNLIFRFVENYISPVAGRISSQRHVMAIRDGFISAMPFMIVGSFLLVFAYPPF
SPDTTWGFARAWLDLAKEFEGRILTPFDMTMGIMSIYICAAIAYNLGKHYEKTDQLDPFM
CAMLSIMAFLLVAAPKTNGNLPVDSLGGTGIFTAILVAVYCVEMMRFLKAHNIGIRLPDQ
VPPMIKNSFDLLIPVLVVVLTLYPLSLLIQHHFDMLIPQAIMAIFKPLVSAADSLPAILL
AVLVGHLLWFAGIHGAAIVSGMLQMFWLTNLGMNQQALAQGAPLPHIFMEAFWTFFIVIG
GSGATMGLVFCYLRSRSAHLRSIGRLSVVPSLFNINEPVIFGTPIVMNPVFFIPFLLAPM
VNAVLAWAAMKMDLIGRVISVVPWTAPAPIGGAWALGWDFRAAILVVVLACVSAIIYFPF
FKVYEKQLLAQEAEEAQRIAEESQQTA