Protein Info for BWI76_RS03840 in Klebsiella michiganensis M5al

Annotation: 4-hydroxyphenylacetate permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 458 transmembrane" amino acids 36 to 57 (22 residues), see Phobius details amino acids 69 to 90 (22 residues), see Phobius details amino acids 102 to 121 (20 residues), see Phobius details amino acids 127 to 150 (24 residues), see Phobius details amino acids 162 to 183 (22 residues), see Phobius details amino acids 195 to 216 (22 residues), see Phobius details amino acids 266 to 291 (26 residues), see Phobius details amino acids 306 to 326 (21 residues), see Phobius details amino acids 338 to 356 (19 residues), see Phobius details amino acids 362 to 383 (22 residues), see Phobius details amino acids 395 to 417 (23 residues), see Phobius details amino acids 428 to 447 (20 residues), see Phobius details TIGR02332: 4-hydroxyphenylacetate permease" amino acids 28 to 439 (412 residues), 855 bits, see alignment E=5e-262 PF07690: MFS_1" amino acids 40 to 413 (374 residues), 173.1 bits, see alignment E=4e-55

Best Hits

KEGG orthology group: K02511, MFS transporter, ACS family, 4-hydroxyphenylacetate permease (inferred from 98% identity to kva:Kvar_4470)

Predicted SEED Role

"4-hydroxyphenylacetate symporter, major facilitator superfamily (MFS)" in subsystem 4-Hydroxyphenylacetic acid catabolic pathway

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AY17 at UniProt or InterPro

Protein Sequence (458 amino acids)

>BWI76_RS03840 4-hydroxyphenylacetate permease (Klebsiella michiganensis M5al)
MSDTSSAIPEKFDPANQHKQLTAQQQSVINKLFRRLIVFLFVLFIFSFLDRINIGFAGLT
MGQDLGLNATMFGLATTLFYATYVIFGIPSNVMLSIVGARRWIATIMVLWGIASTATMFA
TGPNSLYILRMLVGITEAGFLPGILLYLTYWFPAFFRARANALFMIAMPVTTALGSIVSG
YILSMDGLLNLHGWQWLFLLEGFPSVLLGIMVWFWLDDSPSKAKWLTAEDKKCLQEMMDN
DRLTLVQPEGAISHHAMQQRSLWREVFTPIVLMYTLAYFCLTNTLSAISIWTPQILKSFN
ESSSNITIGLLAAIPQICTILGMIYWSRHSDKHQERKHHTALPFLFAAAGWLLASATDHS
LIQLFGIVMASTGSFSAMAIFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLK
DITGSFSSGLWFVAALLVIGAVIIWAIPMKGSRPRATP