Protein Info for BWI76_RS03810 in Klebsiella michiganensis M5al

Annotation: GTPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02492: cobW
  • amino acids 6 to 183 (178 residues), 186.5 bits, E=3.7e-59
• PF07683: CobW_C
  • amino acids 224 to 316 (93 residues), 72.9 bits, E=1.6e-24

Best Hits

Swiss-Prot: 88% identical to YJIA_ECOLI: P-loop guanosine triphosphatase YjiA (yjiA) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 91% identity to sea:SeAg_B4857)

MetaCyc: 88% identical to P-loop guanosine triphosphatase YjiA (Escherichia coli K-12 substr. MG1655)
3.6.1.15,3.6.5.6,3.6.5.5,3.6.5.4,3.6.5.3,3.6.5.2,3.6.5.1,3.6.1.-,3.6.1.5 [EC: 3.6.1.15, 3.6.1.5, 3.6.5.1, 3.6.5.2, 3.6.5.3, 3.6.5.4, 3.6.5.5, 3.6.5.6]

Predicted SEED Role

"Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family"

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (14/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (6/8 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• UTP and CTP dephosphorylation II (1/3 steps found)

KEGG Metabolic Maps

• Purine metabolism
• Pyrimidine metabolism
• Thiamine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.15

Use Curated BLAST to search for 3.6.1.15 or 3.6.1.5 or 3.6.5.1 or 3.6.5.2 or 3.6.5.3 or 3.6.5.4 or 3.6.5.5 or 3.6.5.6

Sequence Analysis Tools

See A0A285AXZ9 at UniProt or InterPro

Protein Sequence (318 amino acids)

>BWI76_RS03810 GTPase (Klebsiella michiganensis M5al)
MAPIAVTLLTGFLGAGKTTLLRHILNERHGFKIAVIENEFGEVAIDNQLIGDRATQIKTL
TNGCICCTRSNELEDALLDLLDSRDRGDIAFDRLVIECTGMADPGPIIQTFFSHDVLCER
YLLDGVIALVDAVHADQQMNQFTIAQSQVGYADRILLTKTDVAGDSDKLRERLTRINARA
PIYNVTHGDIDLNLLFNTSGFMLEENVVSSKPRFHFMADKQNDVSSIVVELDYPVDISEV
SRVMENLLLTFAEQLMRYKGMLWIDGEPNRLLFQGVQRLYSADWDRPWGDERPHSTLVFI
GIQLPEDEIRTAFESLRR