Protein Info for BWI76_RS03795 in Klebsiella michiganensis M5al

Annotation: putative aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 3 to 452 (450 residues), 462.7 bits, E=5.8e-143

Best Hits

Swiss-Prot: 48% identical to GABD_DEIRA: Succinate-semialdehyde dehydrogenase [NADP(+)] (ssdA) from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 92% identity to kpn:KPN_04772)

MetaCyc: 45% identical to NAD-dependent succinate-semialdehyde dehydrogenase (Synechocystis sp. PCC 6803)
Succinate-semialdehyde dehydrogenase. [EC: 1.2.1.24]

Predicted SEED Role

"Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)" (EC 1.2.1.16, EC 1.2.1.24)

MetaCyc Pathways

• superpathway of L-arginine and L-ornithine degradation (13/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (11/11 steps found)
• superpathway of 4-aminobutanoate degradation (3/3 steps found)
• 4-aminobutanoate degradation I (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• GABA shunt I (3/4 steps found)
• GABA shunt II (2/4 steps found)
• 4-aminobutanoate degradation IV (1/3 steps found)
• N-methylpyrrolidone degradation (1/3 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16, 1.2.1.24

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.24

Sequence Analysis Tools

See A0A285AY49 at UniProt or InterPro

Protein Sequence (456 amino acids)

>BWI76_RS03795 putative aldehyde dehydrogenase (Klebsiella michiganensis M5al)
MAYQTVNPANNQLIKAYPSHSDADVEAALQKADALYHSSWSKGDIAQRLSVLHKLADLID
SRVDELAKIASQEMGKLIEQSRGEVKLCAQIARYYADNAKQFLAPVKYPSELGEAWVEHH
PIGVLMAVEPWNFPYYQLMRVLAPNLAAGNPVIAKHASIVPHCAETFAHLVREAGAPEGA
WTNLFISQDQVAKIIADDRVQGAALTGSEKAGSVVAAQAAKHIKKATLELGGNDVFVVLD
DADLAKAVKIGVQARLNNAGQVCTAAKRFILHEKIADAFLSQFTEAFRQVKIGDPLDEST
TLGPLSSKDALETLTRQVNDALKNGAKLHLGGKPAQREGSFFEPTILTGITRDNPAYFEE
FFGPVAQIYVVKDDDEAVKLANDSHYGLGGAVFSQDIERAKRMASRIETGMVYINWLTDT
APELPFGGVKRSGFGRELSDLGIKEFVNQKLVVVHK