Protein Info for BWI76_RS03560 in Klebsiella michiganensis M5al

Annotation: propanediol utilization phosphotransacylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF06130: PTAC
  • amino acids 22 to 101 (80 residues), 68.4 bits, E=4e-23
  • amino acids 131 to 196 (66 residues), 85.8 bits, E=1.5e-28

Best Hits

Swiss-Prot: 56% identical to PDUL_THEMA: Phosphate propanoyltransferase (pduL) from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

KEGG orthology group: None (inferred from 94% identity to kpe:KPK_4886)

MetaCyc: 55% identical to phosphate propanoyltransferase (Salmonella enterica enterica serovar Typhimurium str. LT2)
Phosphate acetyltransferase. [EC: 2.3.1.8]; PTAALT-RXN [EC: 2.3.1.8, 2.3.1.222]

Predicted SEED Role

"Ethanolamine utilization protein similar to PduL" in subsystem Ethanolamine utilization

MetaCyc Pathways

• superpathway of N-acetylneuraminate degradation (22/22 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (19/19 steps found)
• superpathway of L-threonine metabolism (18/18 steps found)
• mixed acid fermentation (16/16 steps found)
• heterolactic fermentation (16/18 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (9/9 steps found)
• L-threonine degradation I (6/6 steps found)
• (S)-propane-1,2-diol degradation (5/5 steps found)
• ethanolamine utilization (5/5 steps found)
• pyruvate fermentation to acetate and (S)-lactate I (4/4 steps found)
• pyruvate fermentation to acetate and lactate II (4/4 steps found)
• pyruvate fermentation to acetate I (3/3 steps found)
• pyruvate fermentation to acetate II (3/3 steps found)
• pyruvate fermentation to acetate IV (3/3 steps found)
• pyruvate fermentation to acetate VII (3/3 steps found)
• superpathway of acetate utilization and formation (3/3 steps found)
• (S)-lactate fermentation to propanoate, acetate and hydrogen (10/13 steps found)
• acetate and ATP formation from acetyl-CoA I (2/2 steps found)
• superpathway of L-alanine fermentation (Stickland reaction) (7/9 steps found)
• acetylene degradation (anaerobic) (4/5 steps found)
• acetyl-CoA fermentation to butanoate (5/7 steps found)
• purine nucleobases degradation II (anaerobic) (17/24 steps found)
• sulfoacetaldehyde degradation I (1/2 steps found)
• superpathway of Clostridium acetobutylicum acidogenic fermentation (6/9 steps found)
• lactate fermentation to acetate, CO₂ and hydrogen (Desulfovibrionales) (5/8 steps found)
• superpathway of taurine degradation (3/6 steps found)
• sulfolactate degradation II (1/4 steps found)
• methanogenesis from acetate (2/6 steps found)
• superpathway of sulfolactate degradation (2/6 steps found)
• gallate degradation III (anaerobic) (5/11 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (9/17 steps found)
• L-lysine fermentation to acetate and butanoate (3/10 steps found)
• superpathway of methanogenesis (2/21 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Pyruvate metabolism
• Taurine and hypotaurine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.8

Use Curated BLAST to search for 2.3.1.222 or 2.3.1.8

Sequence Analysis Tools

See A0A285AXV0 at UniProt or InterPro

Protein Sequence (206 amino acids)

>BWI76_RS03560 propanediol utilization phosphotransacylase (Klebsiella michiganensis M5al)
MIDTLLHEKIAARLSHVAPAIPVGISNRHVHLAQQDVEALFGKGYVLTPFKPLRQPGQFA
AQECVTVVGPKGSLTQVRVLGPTRPVSQLEISRADCFTLGIKAPVRESGQLENAGSALLI
GPAGHVELRSQVICAWRHIHMSPQDARHLNVANGQKVSVRSDGERQLTFDEVVVRVREDF
ALEFHIDTEEANAAGLKNGAQVTLIG