Protein Info for BWI76_RS03510 in Klebsiella michiganensis M5al

Annotation: multidrug ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 909 transmembrane" amino acids 559 to 578 (20 residues), see Phobius details amino acids 714 to 736 (23 residues), see Phobius details amino acids 764 to 787 (24 residues), see Phobius details amino acids 793 to 815 (23 residues), see Phobius details amino acids 822 to 842 (21 residues), see Phobius details amino acids 883 to 904 (22 residues), see Phobius details PF00005: ABC_tran" amino acids 20 to 168 (149 residues), 92.3 bits, see alignment E=1.1e-29 amino acids 285 to 428 (144 residues), 101.5 bits, see alignment E=1.6e-32 PF12698: ABC2_membrane_3" amino acids 564 to 901 (338 residues), 142.4 bits, see alignment E=5e-45 PF12679: ABC2_membrane_2" amino acids 644 to 906 (263 residues), 52.5 bits, see alignment E=1.2e-17 PF01061: ABC2_membrane" amino acids 721 to 872 (152 residues), 61.5 bits, see alignment E=2.1e-20

Best Hits

Swiss-Prot: 85% identical to RBBA_ECOLI: Ribosome-associated ATPase (rbbA) from Escherichia coli (strain K12)

KEGG orthology group: K13926, ribosome-dependent ATPase (inferred from 69% identity to bav:BAV1814)

Predicted SEED Role

"ABC-type multidrug transport system, permease component"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AXU0 at UniProt or InterPro

Protein Sequence (909 amino acids)

>BWI76_RS03510 multidrug ABC transporter ATP-binding protein (Klebsiella michiganensis M5al)
MKTVARLENVSQRFGATVALKDITLSIPARCMVGLIGPDGVGKSSLLSLISGARVIERGN
VMVLGGDMRDVRHRQDVCPKIAWMPQGLGKNLYHTLSVYENVDFFARLFGHDKAERDIRI
NELLQSTGLAPFRDRPAGKLSGGMKQKLGLCCALIHDPQLLILDEPTTGVDPLSRAQFWD
LIDNIRQRQPEMSVLVATAYMEEAERFDWLVAMNAGEVLATGSADELKAHTASQTLEQAF
IALLPDAQRLAHKEVIIPPRHTDEDEIAIEARGLTMRFGNFVAVDHVNFRIARGEIFGFL
GSNGCGKSTTMKMLTGLLPASEGEAWLFGQPVDPRDIETRRRVGYMSQAFSLYSELTVRQ
NLELHARLFHIPKAEIPGRIAEMSQRFMLEEVEDTLPASLPLGIRQRLSLAVAVIHRPEM
LILDEPTSGVDPVARDMFWQLMVDLARQDRVTIFISTHFMNEAERCDRISLMHAGKVLAS
DTPQALVEQRGSASLEEAFIAWLQEAADTAQPPDAKAAPVPAIEHKTESVAPRQTFSLQR
LFSYSRREALELRRDPVRSTLALLGTVILMFIMGYGISMDVEDLRFAVLDRDQTVSSQGW
SQNIAGSRYFIEQPPLQSYSELDRRMRNGELAVAIEIPPNFGRDIARGTPVQIGVWVDGA
MPNRAETVRGYVQAMHLAWLQEMAGRQSSPNRDTSLISIETRYRYNPDVKSLPAIVPAVI
PLLLMMIPAMLSALSVVREKELGSIINLYVTPTTRSEFLLGKQVPYIVLGMFNFFLLCAL
SVFVFGVPHKGSFLTLTLAALLYVTIATGLGLLISTFMKSQIAAIFGTAIITLIPATQFS
GMIDPVASLEGPGRWIGQIYPTSHFLTIARGTFSKALNLTDLWGSFIPLLIAVPLVLGLS
VWLLKKQEG