Protein Info for BWI76_RS02980 in Klebsiella michiganensis M5al

Annotation: type I magnesium transporting ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 902 transmembrane" amino acids 95 to 116 (22 residues), see Phobius details amino acids 122 to 141 (20 residues), see Phobius details amino acids 295 to 313 (19 residues), see Phobius details amino acids 321 to 346 (26 residues), see Phobius details amino acids 707 to 727 (21 residues), see Phobius details amino acids 732 to 751 (20 residues), see Phobius details amino acids 772 to 795 (24 residues), see Phobius details amino acids 807 to 825 (19 residues), see Phobius details amino acids 837 to 858 (22 residues), see Phobius details amino acids 873 to 891 (19 residues), see Phobius details TIGR01524: magnesium-translocating P-type ATPase" amino acids 39 to 902 (864 residues), 1590.5 bits, see alignment E=0 PF00690: Cation_ATPase_N" amino acids 51 to 116 (66 residues), 57.4 bits, see alignment 2.3e-19 TIGR01494: HAD ATPase, P-type, family IC" amino acids 127 to 411 (285 residues), 121.8 bits, see alignment E=2.7e-39 amino acids 610 to 732 (123 residues), 106.5 bits, see alignment E=1.2e-34 PF00122: E1-E2_ATPase" amino acids 162 to 355 (194 residues), 146.7 bits, see alignment E=1.4e-46 PF00702: Hydrolase" amino acids 372 to 657 (286 residues), 57.1 bits, see alignment E=8.3e-19 PF13246: Cation_ATPase" amino acids 433 to 484 (52 residues), 37.4 bits, see alignment 5.1e-13 PF00689: Cation_ATPase_C" amino acids 726 to 893 (168 residues), 76.9 bits, see alignment E=4.5e-25

Best Hits

Swiss-Prot: 88% identical to ATMA_SALT1: Magnesium-transporting ATPase, P-type 1 (mgtA) from Salmonella typhimurium (strain 14028s / SGSC 2262)

KEGG orthology group: None (inferred from 95% identity to eae:EAE_09705)

Predicted SEED Role

"Mg(2+) transport ATPase, P-type (EC 3.6.3.2)" (EC 3.6.3.2)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.2

Use Curated BLAST to search for 3.6.3.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AWV4 at UniProt or InterPro

Protein Sequence (902 amino acids)

>BWI76_RS02980 type I magnesium transporting ATPase (Klebsiella michiganensis M5al)
MLKNFTRQLFAQLGRHLPRRLVQRDPLPDARNLASAPIPDSLGKQCLNVAAMDENEIWRA
FASHPEGLNEGEVAQKIAQYGENQIPAQKPSPWWVHLWSCYRNPFNLLLTVLGIVSYSTE
DLFAAAVIALMVGISTLLNFIQEARSTKAADALKAMVSNTATVLRVVNEQGESRWCELPI
DQLVPGDIVKLSAGDMIPADLRIIQARDLFVAQASLTGESLPVEKVTRTRDPLQTNPLEC
DTLCFMGTNVVSGSAQAIVFATGGGTWFGQLAGRVSEQESEPNAFQKGISRVSMLLIRFM
LVMTPIVLLINGYTKGDWWEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVK
HLDAIQNFGAMDILCTDKTGTLTQDKIVLENHTDVSGKVSERVLHTAWLNSHYQTGLKNL
LDTAVLEGVELEPARGLAERWQKVDEIPFDFERRRMSVVVQEQDNVHQLICKGALQEILN
VSTQVRYNGDIVPLDDTMLRRIRRVTDTLNRQGLRVVAVATKYLPAREGDYQRADESDLI
LEGYIAFLDPPKETTAPALKALKASGITVKILTGDSELVAAKVCHEVGLDAGDVVIGSQV
EALNDDELAELAKRTTLFARLAPLHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGI
SVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNFGNVFSVLVA
SAFLPFLPMLPLHLLIQNLLYDVSQVAIPFDNVDDEQIRKPQRWNPADLGRFMVFFGPIS
SIFDILTFCLMWWVFHANTPEHQTLFQSGWFVVGLLSQTLIVHMIRTRRIPFIQSRAAWP
LIVMTLLVMVVGIALPFSPLAGYLQLQALPLSYFPWLIAILAGYMTLTQMVKGFYSRRYG
WQ