Protein Info for BWI76_RS02750 in Klebsiella michiganensis M5al

Annotation: DNA-binding transcriptional regulator AraC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 290 PF02311: AraC_binding" amino acids 38 to 162 (125 residues), 52.8 bits, see alignment E=5.3e-18 PF00165: HTH_AraC" amino acids 192 to 232 (41 residues), 28.9 bits, see alignment 1.5e-10 PF12833: HTH_18" amino acids 205 to 284 (80 residues), 83.8 bits, see alignment E=1.3e-27

Best Hits

Swiss-Prot: 44% identical to ARAC_DICCH: Arabinose operon regulatory protein (araC) from Dickeya chrysanthemi

KEGG orthology group: None (inferred from 93% identity to kva:Kvar_4644)

Predicted SEED Role

"Arabinose operon regulatory protein" in subsystem L-Arabinose utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AWX8 at UniProt or InterPro

Protein Sequence (290 amino acids)

>BWI76_RS02750 DNA-binding transcriptional regulator AraC (Klebsiella michiganensis M5al)
MELDINELLNFSPLMKTFTFNAWVVAGFTPITRGSKLDYYINRPQGMKGYIINLTLRGQA
RAKAGDGSLLFRENDLLLFPPGVPHHYGRDEHSDYWDHLWIYFIPRPYWIDWLKWDQTAH
GIGKTTVNDPEQLQSLRDLFYEVIRHHSASAPLSEALAMNALERLILSCFQRQPISNRHA
HDPRINAVCDYLNEHIAQEIKIENLAAMVFISPSRLAHLFKNELGQTVYAWREAQRINRA
KWLIQTTSLPLNKIALSVGYGDPVYFTRIFRKHNGIPPGEYRKRYAEMKG