Protein Info for BWI76_RS02325 in Klebsiella michiganensis M5al

Annotation: anaerobic C4-dicarboxylate transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 433 transmembrane" amino acids 6 to 39 (34 residues), see Phobius details amino acids 48 to 68 (21 residues), see Phobius details amino acids 87 to 110 (24 residues), see Phobius details amino acids 131 to 157 (27 residues), see Phobius details amino acids 164 to 190 (27 residues), see Phobius details amino acids 227 to 247 (21 residues), see Phobius details amino acids 261 to 277 (17 residues), see Phobius details amino acids 289 to 307 (19 residues), see Phobius details amino acids 328 to 346 (19 residues), see Phobius details amino acids 357 to 382 (26 residues), see Phobius details amino acids 408 to 431 (24 residues), see Phobius details TIGR00770: transporter, anaerobic C4-dicarboxylate uptake (Dcu) family" amino acids 5 to 433 (429 residues), 654.1 bits, see alignment E=5.5e-201 PF03605: DcuA_DcuB" amino acids 5 to 365 (361 residues), 524.6 bits, see alignment E=6.7e-162

Best Hits

Swiss-Prot: 71% identical to DCUA_WOLSU: Anaerobic C4-dicarboxylate transporter DcuA (dcuA) from Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)

KEGG orthology group: None (inferred from 97% identity to eae:EAE_09110)

MetaCyc: 62% identical to C4-dicarboxylate transporter DcuA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-106; TRANS-RXN-106A; TRANS-RXN-106B; TRANS-RXN-299; TRANS-RXN-379

Predicted SEED Role

"C4-dicarboxylate transporter DcuA"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AWH9 at UniProt or InterPro

Protein Sequence (433 amino acids)

>BWI76_RS02325 anaerobic C4-dicarboxylate transporter (Klebsiella michiganensis M5al)
MFGAELVIVLLAIYLGARLGGIGIGFAGGLGVLVLTLVFQIKPGAIPFDVIEIIMAVIAA
IAAMQVAGGMDYLVSLAERMLRRHPKYITFLAPLVTWFMTVLAGTGHTAFSTLPVITEVA
KEQGIRPSRPLSIAVVASQIAITASPISAAVVFFAGILEPLGVSYLTLLAICIPVTLIAV
MLTAIVCNFLGCELKDDPIYQERLAKGEVKLRGSQVFELKPHARRSVLLFLIGIIAVMFY
ATAISDTVGLIQNPVLPRNEAIVVFMLTIATLISITCKIDTGEVLNASTFKSGMSACVCV
LGVAWLGDTFVKAHISDIQTVAGDLLHNYPWLLAVVLFFAATLLYSQAATTKALMPAALM
LGVSPLTAIASFAAVSALFVLPTYPTLLAAVEMDDTGSTRIGKYVFNHAFLIPGVIAITL
CVILGFIFGGIML