Protein Info for BWI76_RS02160 in Klebsiella michiganensis M5al

Annotation: D-allose transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 510 PF00005: ABC_tran" amino acids 21 to 174 (154 residues), 107 bits, see alignment E=1.2e-34 amino acids 280 to 437 (158 residues), 85.1 bits, see alignment E=7.2e-28

Best Hits

Swiss-Prot: 91% identical to ALSA_ECOLI: D-allose import ATP-binding protein AlsA (alsA) from Escherichia coli (strain K12)

KEGG orthology group: K10551, D-allose transport system ATP-binding protein [EC: 3.6.3.17] (inferred from 93% identity to cko:CKO_03786)

MetaCyc: 91% identical to D-allose ABC transporter ATP binding subunit (Escherichia coli K-12 substr. MG1655)
ABC-42-RXN [EC: 7.5.2.8]

Predicted SEED Role

"D-allose ABC transporter, ATPase component" in subsystem D-allose utilization

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.17

Use Curated BLAST to search for 3.6.3.17 or 7.5.2.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AWI6 at UniProt or InterPro

Protein Sequence (510 amino acids)

>BWI76_RS02160 D-allose transporter ATP-binding protein (Klebsiella michiganensis M5al)
MLTPYISMAGIGKSFGPVHALKSVDLTIYPHEIHALLGENGAGKSTLMKVLSGIHEPTKG
TITINNVNYDKLDHKLAAQLGIGIIYQELSVIDELTVLENLYIGRHLTKKVCGVNVIDWR
EMRVRAAMMLLRVGLKIDLDEKVVNLSISHKQMLEIAKTLMLDAKVLIMDEPTSSLTNKE
VDYLFLIMNQLRKEGTAIVYISHKLAEIRRICDRYTVMKDGSSVCSGMVSEVNNDDIVRL
MVGRELQNRFNAMKESTGNIVRETVFEVKNVTSHDKKKVRDISFSVNRGEILGFAGLVGS
GRTELMDCLFGVDKRSGGEIYLNGKAISPRSPLDALKKGMGYITESRRENGFFPNFSIAQ
NMAVSQSLKRGGYKGAMGLFREGDERKTAEEQRKLLALKCHSVDQNITELSGGNQQKVLI
SKWLCCSPEVIIFDEPTRGIDVGAKAEIYKVMRQLADDGKVILMVSSELPEIIAVCDRIA
VFCEGRLTQILTNRDDLSEEEIMAWALPQE