Protein Info for BWI76_RS02040 in Klebsiella michiganensis M5al
Annotation: aryl-alcohol dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 59% identical to XYLB_PSEPU: Aryl-alcohol dehydrogenase (xylB) from Pseudomonas putida
KEGG orthology group: K00055, aryl-alcohol dehydrogenase [EC: 1.1.1.90] (inferred from 64% identity to nde:NIDE0023)MetaCyc: 59% identical to benzyl alcohol dehydrogenase subunit (Pseudomonas putida mt-2)
Aryl-alcohol dehydrogenase. [EC: 1.1.1.90]; 1.1.1.90 [EC: 1.1.1.90]; 1.1.1.90 [EC: 1.1.1.90]; 1.1.1.90 [EC: 1.1.1.90]
Predicted SEED Role
"AreB (Aryl-alcohol dehydrogenase) (EC 1.1.1.90)" in subsystem Salicylate and gentisate catabolism or Salicylate ester degradation (EC 1.1.1.90)
MetaCyc Pathways
- 1,3-dimethylbenzene degradation to 3-methylbenzoate (1/3 steps found)
- 1,4-dimethylbenzene degradation to 4-methylbenzoate (1/3 steps found)
- 3-chlorotoluene degradation II (1/3 steps found)
- toluene degradation to benzoate (1/3 steps found)
- toluene degradation IV (aerobic) (via catechol) (7/13 steps found)
- m-cresol degradation (1/5 steps found)
- salicin biosynthesis (1/6 steps found)
- 2,5-xylenol and 3,5-xylenol degradation (5/13 steps found)
- salicortin biosynthesis (1/9 steps found)
- superpathway of aerobic toluene degradation (15/30 steps found)
KEGG Metabolic Maps
- Biphenyl degradation
- Caprolactam degradation
- Phenylalanine metabolism
- Toluene and xylene degradation
- Tyrosine metabolism
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.1.1.90
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A285AWB2 at UniProt or InterPro
Protein Sequence (375 amino acids)
>BWI76_RS02040 aryl-alcohol dehydrogenase (Klebsiella michiganensis M5al) MTEHCALPGSFKAAVVRQPGGPFELETVQLNSLQPHEVVVRIVATGMCHTDMVARDRLYP IPQPIVLGHEGAGVVEAVGAEVQKVVPGDHVVLTFLSCGACRPCLEGVPASCQNFNALNF SGQRSDGSHALCHHGNQTLHDRFFGQSSFAAFSVVDQRNLVKVRPDAPLELLGPLGCGIQ TGAGAVLNALKVAAGSSFAAFGGGTVGLSGVMAAYVAGATTIIVIDVVEERLALARELGA THVINSKKEDPVEAIRHITGDGVDFSLESTGRPEIVRAAVEALRPRGMCGIVGASKTGTT FALDMNDVMQKCKVLRGIVEGDSIPDIFIPQLVELYVQGRFPIDKLIRFYPFEEINQAAH DSECGKTIKPVIRIG