Protein Info for BWI76_RS01965 in Klebsiella michiganensis M5al

Annotation: TonB-dependent siderophore receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 753 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF07715: Plug" amino acids 62 to 176 (115 residues), 90.5 bits, see alignment E=9.8e-30 TIGR01783: TonB-dependent siderophore receptor" amino acids 63 to 753 (691 residues), 396.3 bits, see alignment E=1.4e-122 PF00593: TonB_dep_Rec" amino acids 290 to 707 (418 residues), 180.1 bits, see alignment E=1.5e-56

Best Hits

Swiss-Prot: 73% identical to FEPA_ECOLI: Ferrienterobactin receptor (fepA) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 77% identity to eae:EAE_13600)

MetaCyc: 73% identical to ferric enterobactin outer membrane transporter (Escherichia coli K-12 substr. MG1655)
RXN0-1682

Predicted SEED Role

"TonB-dependent receptor; Outer membrane receptor for ferric enterobactin and colicins B, D"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AWE5 at UniProt or InterPro

Protein Sequence (753 amino acids)

>BWI76_RS01965 TonB-dependent siderophore receptor (Klebsiella michiganensis M5al)
MKYDSHYSLAVLIPMVIWGGTLPVQAADGSMPDDTKKSETAAVNDDETMVVTAAAQTLQA
PGVSTITAEEIRKHPPARDVSELIRTQPGVNLTGNSTSGQRGNNRQVDIRGMGPENTLIL
VDGKPVTSRNSVRYGWRGDRDTRGDTSWVPAEMIDHIDVIRGPAAARYGNGAMGGVVNIV
TKPATSEWHGSWNTYMNAPQHRKEGATKRTNFSLNGPLSDEVSFNLWGNLSKTQADAQDI
NAGHEAARTGSYAGSYPAGREGVVNKDIHGKLRWEFAPMQALEFETGYSRQGNLYAGDTQ
NTNTSTLVKSLYGKETNRLYRQTYGVTWTGGWDNGVTSNTWAQYEHTRNSRMNEGLAGGT
EGIFSSSEFSDIDLSDVLLHSEVNIPFTLGFEQNLTLGTEWNQQRMKDGVSTTQSLSYGS
IDGMSATGRSPYSSAEIFSLFTEDNIALTESTMLTPALRFDHHSIVGNNWSPSLNLSQGL
SDDWTLKLGIARAYKAPNLYQLNPNYILYSNGQGCYASSSACYLMGNSDLKAETSVNKEI
GLEYKHNGYQAGLTWFRNDYHNKIESGYSAVGTASNGTTNIYQWENVPKALVEGLEGSLN
LPVSETVNWSNNLTWMLQSKNKTTGDRLSVIPQFTLNSTVSWQVRDDLSLQSTFTWYGRQ
KPKRFNYKGEAVSGSELNEVSPYSIVGLSATWDVNKNLSLTSGVDNLFDIRHYRAGNAQT
TGNSTTGAYLYGAGAETYNESGRTFYISVNTHF