Protein Info for BWI76_RS01950 in Klebsiella michiganensis M5al

Annotation: excinuclease ABC subunit A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 941 TIGR00630: excinuclease ABC subunit A" amino acids 3 to 925 (923 residues), 1528.6 bits, see alignment E=0 PF17760: UvrA_inter" amino acids 130 to 237 (108 residues), 130.4 bits, see alignment E=7.8e-42 PF17755: UvrA_DNA-bind" amino acids 290 to 399 (110 residues), 130.1 bits, see alignment E=1.3e-41 PF00005: ABC_tran" amino acids 806 to 861 (56 residues), 26.2 bits, see alignment 3.3e-09

Best Hits

Swiss-Prot: 96% identical to UVRA_ECO57: UvrABC system protein A (uvrA) from Escherichia coli O157:H7

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 81% identity to aat:D11S_0457)

MetaCyc: 96% identical to UvrABC excision nuclease subunit A (Escherichia coli K-12 substr. MG1655)
3.1.25.-

Predicted SEED Role

"Excinuclease ABC subunit A" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AWH8 at UniProt or InterPro

Protein Sequence (941 amino acids)

>BWI76_RS01950 excinuclease ABC subunit A (Klebsiella michiganensis M5al)
MDKIEVRGARTHNLKNINLVIPRDKLIVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAY
ARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTITEIHDYLRLLYARVGEPRC
PDHDVPLAAQTVSQMVDNVLSQPEGQRLMLLAPIIKERKGEHNKTLENLAGQGYIRARID
GEVCDLSDPPKLELQKKHTIEVVIDRFKVRDDLSTRLAESFETALELSGGTAIVANMDDP
KAEELLFSANFACPICGYSMRELEPRLFSFNNPAGACPTCDGLGVQQYFDPERVIQNPEL
SLAGGAIRGWDRRNFYYFQMLKSLAEHYEFDVEAPWGTLNSSVQKVVLYGSGKENIEFKY
MNDRGDTSVRRHPFEGVLHNMERRYKETESSAVREELAKFISNRPCTSCEGTRLKREARH
VFVENTPLPTISDMSIGHAMDFFNNLKLSGQRAQIAEKVLKEIGDRLKFLVNVGLNYLTL
SRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLGTLIHLRNLGNT
VIVVEHDEDAIRAADHVIDIGPGAGVHGGQVVAEGKLEDIMAVPESLTGQFMSGKRKIEV
PKQRVPANPEKVLKLSGARGNNLKDVTLTLPVGLFTCITGVSGSGKSTLINDTLFPIAQR
QLNGATIAEPAPYRDVQGLEHFDKVIDIDQSPIGRTPRSNPATYTGVFTPVRELFAGVPE
SRSRGYTPGRFSFNVRGGRCEACQGDGVIKVEMHFLPDIYVPCDQCKGKRYNRETLEIKY
KGKTIHEVLDMTIEEAREFFDAVPALARKLQTLMDVGLTYIRLGQSATTLSGGEAQRVKL
ARELSKRGTGQTLYILDEPTTGLHFADIQQLLEVLHQLRDQGNTIVVIEHNLDVIKTADW
IVDLGPEGGSGGGEILVSGTPETVAECEASYTARFLKPMLK