Protein Info for BWI76_RS01740 in Klebsiella michiganensis M5al

Annotation: PTS enzyme IIAB, mannose-specific

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00824: PTS system, mannose/fructose/sorbose family, IIA component
  • amino acids 1 to 114 (114 residues), 150.6 bits, E=9.4e-49
• PF03610: EIIA-man
  • amino acids 4 to 113 (110 residues), 59.5 bits, E=1.7e-20

Best Hits

Swiss-Prot: 80% identical to PTRA_KLEPN: PTS system sorbose-specific EIIA component (sorF) from Klebsiella pneumoniae

KEGG orthology group: K02812, PTS system, sorbose-specific IIA component [EC: 2.7.1.69] (inferred from 80% identity to kpn:KPN_04406)

Predicted SEED Role

"PTS system, sorbose-specific IIA component"

KEGG Metabolic Maps

• Aminosugars metabolism
• Ascorbate and aldarate metabolism
• Fructose and mannose metabolism
• Galactose metabolism
• Glycolysis / Gluconeogenesis
• Nucleotide sugars metabolism
• Starch and sucrose metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.69

Sequence Analysis Tools

See A0A285AW57 at UniProt or InterPro

Protein Sequence (135 amino acids)

>BWI76_RS01740 PTS enzyme IIAB, mannose-specific (Klebsiella michiganensis M5al)
MVNVIFCAHGQLACAMLDSVRMVYGDVNVSAVEFVPGENSGDIADKLEKLVSTHKEEEWL
IAVDLQCGSPWNAAAGLAMRNPRLRVISGLSLPLALELVDNQQTMHAEELCQHLETIASQ
CCVTWRQPETVEEDF