Protein Info for BWI76_RS01570 in Klebsiella michiganensis M5al

Annotation: uroporphyrinogen decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01208: URO-D
  • amino acids 5 to 347 (343 residues), 480.8 bits, E=1.1e-148
• TIGR01464: uroporphyrinogen decarboxylase
  • amino acids 9 to 347 (339 residues), 453.1 bits, E=2.7e-140

Best Hits

Swiss-Prot: 97% identical to DCUP_ECO7I: Uroporphyrinogen decarboxylase (hemE) from Escherichia coli O7:K1 (strain IAI39 / ExPEC)

KEGG orthology group: K01599, uroporphyrinogen decarboxylase [EC: 4.1.1.37] (inferred from 96% identity to eco:b3997)

MetaCyc: 96% identical to uroporphyrinogen decarboxylase (Escherichia coli K-12 substr. MG1655)
Uroporphyrinogen decarboxylase. [EC: 4.1.1.37]

Predicted SEED Role

"Uroporphyrinogen III decarboxylase (EC 4.1.1.37)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 4.1.1.37)

MetaCyc Pathways

• superpathway of heme b biosynthesis from glutamate (9/10 steps found)
• superpathway of heme b biosynthesis from uroporphyrinogen-III (6/6 steps found)
• heme b biosynthesis II (oxygen-independent) (4/4 steps found)
• heme b biosynthesis V (aerobic) (4/4 steps found)
• superpathway of heme b biosynthesis from glycine (6/8 steps found)
• heme b biosynthesis I (aerobic) (3/4 steps found)
• heme b biosynthesis IV (Gram-positive bacteria) (1/5 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) (3/9 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent) (2/9 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) (2/9 steps found)
• superpathway of bacteriochlorophyll a biosynthesis (6/26 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.37

Sequence Analysis Tools

See A0A285AW62 at UniProt or InterPro

Protein Sequence (354 amino acids)

>BWI76_RS01570 uroporphyrinogen decarboxylase (Klebsiella michiganensis M5al)
MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRVEAGDFMSLCKNAELACEVT
LQPLRRYKLDAAILFSDILTIPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPVPDPEDE
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYAEPQALHA
LLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGALTGRDYQQFSLYYMHKIVDGLLRENDG
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGHKVALQGNMDPSMLYAP
PARIEEEVATILAGFGQGEGHVFNLGHGIHQDVDPEHAGVFVEAVHRLSAPYHR