Protein Info for BWI76_RS01375 in Klebsiella michiganensis M5al

Annotation: Xaa-Pro dipeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 PF21216: PepQ_N" amino acids 7 to 157 (151 residues), 212.4 bits, see alignment E=3e-67 PF00557: Peptidase_M24" amino acids 168 to 430 (263 residues), 140.4 bits, see alignment E=7.2e-45

Best Hits

Swiss-Prot: 93% identical to PEPQ_KLEP7: Xaa-Pro dipeptidase (pepQ) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K01271, Xaa-Pro dipeptidase [EC: 3.4.13.9] (inferred from 93% identity to kva:Kvar_4891)

MetaCyc: 92% identical to Xaa-Pro dipeptidase (Escherichia coli K-12 substr. MG1655)
Xaa-Pro dipeptidase. [EC: 3.4.13.9]

Predicted SEED Role

"Xaa-Pro dipeptidase PepQ (EC 3.4.13.9)" (EC 3.4.13.9)

Isozymes

Compare fitness of predicted isozymes for: 3.4.13.9

Use Curated BLAST to search for 3.4.13.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AW38 at UniProt or InterPro

Protein Sequence (443 amino acids)

>BWI76_RS01375 Xaa-Pro dipeptidase (Klebsiella michiganensis M5al)
MESLAGLYKNHIVTLQERTRDVLARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWV
PVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEEVEVIALPKADGIGSQLP
AARGNIAYIGPVPERALGLELAADKINPKGVIDYLHYYRSYKTDYELACMREAQKSAVNG
HQAAHEAFLSGMSEFDINQAYLTATGHRDTDVPYSNIVALNEHASVLHYTKLDHRAPAEL
RSFLLDAGAEYNGYAADLTRTWAAHGDNDYAQLVKDVNDEQLALISTMKAGVSYVDYHVQ
FHQRIAKLLRKHQIVKEMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDTGTHL
AAPAKYPYLRCTRVLQPRMVLTIEPGIYFIESLLAPWREGQFSKHFNWQKIEALKPFGGI
RIEDNVVIHENSIENMTRDLKLA