Protein Info for BWI76_RS01170 in Klebsiella michiganensis M5al

Annotation: uroporphyrinogen-III C-methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 389 transmembrane" amino acids 39 to 59 (21 residues), see Phobius details PF04375: HemX" amino acids 132 to 365 (234 residues), 348.9 bits, see alignment E=7.4e-109

Best Hits

Swiss-Prot: 78% identical to HEMX_ECOLI: Protein HemX (hemX) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 88% identity to eae:EAE_07855)

Predicted SEED Role

"Homolog of E. coli HemX protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AVV5 at UniProt or InterPro

Protein Sequence (389 amino acids)

>BWI76_RS01170 uroporphyrinogen-III C-methyltransferase (Klebsiella michiganensis M5al)
MTEQQNQSAVVEETREAVDTTPQPENNVEKKNGGSKTSLALSAIAIAIALAAGIGLYGLT
KTQATRQSEASAGLSSQIAALQKAQENQKSELEGIIKQQADQLTQAQRQQDALAKKLEEV
QEKVAVISGSDAKTWLLAQADFLVKLAGRKLWSDQDVTTAAALLKSADASLADMNDPSLI
SARRAITDDIASLSAVSQVDYDGIILKVNQLANQIDNLRLADNNDDDTPMDSDSDELSSS
ISEWRVNLQKSWQNFMDSFITVRRRDETAVPLLAPNQDVYLRENIRSRLLVAAQAVPRHQ
EETYKQALDNVSTWVRAYYDTEDATTKAFLEDVDKLSQQSITMNVPESLQSQALLEKLMQ
TRVRNLMAQPAETQPSAPAPAPVPAPQGE