Protein Info for BWI76_RS00410 in Klebsiella michiganensis M5al

Annotation: translational GTPase TypA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 607 PF00009: GTP_EFTU" amino acids 4 to 195 (192 residues), 200 bits, see alignment E=7.1e-63 TIGR01394: GTP-binding protein TypA/BipA" amino acids 5 to 599 (595 residues), 968 bits, see alignment E=1.5e-295 TIGR00231: small GTP-binding protein domain" amino acids 5 to 134 (130 residues), 85.3 bits, see alignment E=4e-28 PF01926: MMR_HSR1" amino acids 8 to 129 (122 residues), 26.4 bits, see alignment E=1.6e-09 PF03144: GTP_EFTU_D2" amino acids 219 to 289 (71 residues), 47.7 bits, see alignment E=4.2e-16 PF00679: EFG_C" amino acids 397 to 476 (80 residues), 78.7 bits, see alignment E=7e-26 PF21018: BipA_C" amino acids 485 to 593 (109 residues), 152.7 bits, see alignment E=7.4e-49

Best Hits

Swiss-Prot: 95% identical to TYPA_ECO27: GTP-binding protein TypA/BipA (typA) from Escherichia coli O127:H6 (strain E2348/69 / EPEC)

KEGG orthology group: K06207, GTP-binding protein (inferred from 98% identity to esc:Entcl_4383)

Predicted SEED Role

"GTP-binding protein TypA/BipA" in subsystem Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AVN5 at UniProt or InterPro

Protein Sequence (607 amino acids)

>BWI76_RS00410 translational GTPase TypA (Klebsiella michiganensis M5al)
MIENLRNIAIIAHVDHGKTTLVDKLLQQSGTFDARAETQERVMDSNDLEKERGITILAKN
TAIKWNDYRINIVDTPGHADFGGEVERVMSMVDSVLLVVDAMDGPMPQTRFVTKKAFAHG
LKPIVVINKVDRPGARPDWVVDQVFDLFVNLDATDEQLDFPIVYASALNGIAGLDHEDMA
EDMTPLYQTIVDRVPAPNVDLDGPLQMQISQLDYNNYVGVIGIGRIKRGKVKPNQQVTII
DSEGKTRNGKVGKVLTHLGLERIESDVAEAGDIIAITGLGELNISDTICDTQNVEALPAL
SVDEPTVSMFFCVNTSPFCGKEGKYVTSRQILDRLNKELVHNVALRVEETPDADAFRVSG
RGELHLSVLIENMRREGFEMAVSRPKVIFREIDGRKQEPFENVTLDVEEQHQGSVMQALG
ERKGDLKNMNPDGKGRVRLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDDVRAGDV
GQRQNGVLISNGQGKAVAFALFSLQDRGKLFLGHGAEVYEGQIIGIHSRSNDLTVNCLTG
KKLTNMRASGTDEATTLVPALKMTLEQALEFIDDDELVEVTPTSVRIRKRHLTENDRKRA
MRGAKED