Protein Info for BWI76_RS00090 in Klebsiella michiganensis M5al

Annotation: multidrug transporter subunit MdtL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 393 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details transmembrane" amino acids 40 to 58 (19 residues), see Phobius details amino acids 70 to 90 (21 residues), see Phobius details amino acids 97 to 116 (20 residues), see Phobius details amino acids 128 to 151 (24 residues), see Phobius details amino acids 158 to 178 (21 residues), see Phobius details amino acids 199 to 222 (24 residues), see Phobius details amino acids 242 to 262 (21 residues), see Phobius details amino acids 270 to 288 (19 residues), see Phobius details amino acids 294 to 314 (21 residues), see Phobius details amino acids 325 to 349 (25 residues), see Phobius details amino acids 356 to 376 (21 residues), see Phobius details PF07690: MFS_1" amino acids 11 to 340 (330 residues), 160.7 bits, see alignment E=7.3e-51 PF06609: TRI12" amino acids 25 to 195 (171 residues), 36.7 bits, see alignment E=2.7e-13 PF00083: Sugar_tr" amino acids 35 to 131 (97 residues), 39.7 bits, see alignment E=4.6e-14

Best Hits

Swiss-Prot: 85% identical to MDTL_KLEP3: Multidrug resistance protein MdtL (mdtL) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: None (inferred from 89% identity to eae:EAE_07065)

MetaCyc: 73% identical to efflux pump MdtL (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-341

Predicted SEED Role

"Putative transport protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AVC4 at UniProt or InterPro

Protein Sequence (393 amino acids)

>BWI76_RS00090 multidrug transporter subunit MdtL (Klebsiella michiganensis M5al)
MARFLICSFALVLLYPSGIDMYLVGLPRIAQDLGASEAQLHIAFSVYLAGMAAAMLFAGR
IADKSGRKPVAIFGAVVFILASLICSQAQVSAHFLTGRFIQGIGAGSCYVVAFAVLRDTL
DDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKYPWQSLFYTMTGMGVLVGLLSIFILRE
TRPTSVRQAAQQNVAPESLLNRFFLSRTIVTTLSVTAILTYVNVSPVLMMEVMGFDRGTY
SMAMALMALVSMVVSFSTPFALTLFKPRTLMLTSQVLFFIAGALLSFATSQTITMLGLGL
ICAGFSAGFGVAMSQALGPFTLRAGVASSVLGIAQVCGSSLWIWLAAIIGLSAMNMLIGI
LIACSIVSIVLIMVASPARAAQRYEKTPVESRS