Protein Info for BPHYT_RS31410 in Burkholderia phytofirmans PsJN
Annotation: D-amino acid oxidase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 100% identity to bpy:Bphyt_6338)MetaCyc: 45% identical to tyramine oxidase subunit A (Pseudomonas putida U)
Monoamine oxidase. [EC: 1.4.3.4]; 1.4.3.4 [EC: 1.4.3.4]; 1.4.3.4 [EC: 1.4.3.4]
Predicted SEED Role
"D-amino acid dehydrogenase small subunit (EC 1.4.99.1)" in subsystem Pyruvate Alanine Serine Interconversions or Respiratory dehydrogenases 1 (EC 1.4.99.1)
MetaCyc Pathways
- superpathway of phenylethylamine degradation (11/11 steps found)
- phenylethylamine degradation I (2/2 steps found)
- salidroside biosynthesis (3/4 steps found)
- L-phenylalanine degradation IV (mammalian, via side chain) (6/9 steps found)
- phenylethanol biosynthesis (3/5 steps found)
- L-tryptophan degradation X (mammalian, via tryptamine) (2/4 steps found)
- putrescine degradation III (2/4 steps found)
- L-tryptophan degradation VI (via tryptamine) (1/3 steps found)
- dopamine degradation (2/5 steps found)
- aromatic biogenic amine degradation (bacteria) (4/8 steps found)
- serotonin degradation (3/7 steps found)
- noradrenaline and adrenaline degradation (4/13 steps found)
KEGG Metabolic Maps
- Alkaloid biosynthesis I
- Arginine and proline metabolism
- Drug metabolism - cytochrome P450
- Glycine, serine and threonine metabolism
- Histidine metabolism
- Nitrogen metabolism
- Phenylalanine metabolism
- Tryptophan metabolism
- Tyrosine metabolism
- Urea cycle and metabolism of amino groups
Isozymes
Compare fitness of predicted isozymes for: 1.4.99.1
Use Curated BLAST to search for 1.4.3.4 or 1.4.99.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See B2TB64 at UniProt or InterPro
Protein Sequence (446 amino acids)
>BPHYT_RS31410 D-amino acid oxidase (Burkholderia phytofirmans PsJN) MGPKVDTVADDIKLPERADVVVIGGGIIGVSTALALHEKGLSVAVCEKGHVAGEQSSRNW GWVRVTRRDPREFLLSIESLKIWHTLDRTLGIDTGFNQCGILYVSNDDAVLERHRDWLKR AREIAGDDAFDTREVDTHEVLRLLPGAKQTFKGGIFTPGDARAEPQKAAPAIANALRRKG VSILTPCAVRGIETSGGRASAVVTEHGTIRCDAVVVAGGAWTRYFCGNLGVELPQLLTRA SVLRTEPLEGGPTCSANNEEFAFRKRADGGYTVAYGMRTHADLTPDSFRLFFKYIEALKS QMGALQIQIGKRFFDELKRPRRWPLNESTVFEHVRTLDPDPVVPYVDKGFKAFTEAFPQL AGARIAQRWAGYIDVTPDAIPVISGVERVPGMFIATGFSGHGFGIGPGAGRLMADLVNHD APLVNPHAFRLERFSDGSKITIDAGF