Protein Info for BPHYT_RS21465 in Burkholderia phytofirmans PsJN

Annotation: TetR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 242 PF00440: TetR_N" amino acids 26 to 72 (47 residues), 46.6 bits, see alignment 2.3e-16 PF17938: TetR_C_29" amino acids 94 to 212 (119 residues), 133 bits, see alignment E=6.1e-43

Best Hits

Swiss-Prot: 56% identical to NICS_PSEPK: HTH-type transcriptional repressor NicS (nicS) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: None (inferred from 100% identity to bpy:Bphyt_4322)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B2TF28 at UniProt or InterPro

Protein Sequence (242 amino acids)

>BPHYT_RS21465 TetR family transcriptional regulator (Burkholderia phytofirmans PsJN)
MSSTAARKPGATGIRAKQAQDTRAKILKAAIKVFAKQGYASGRVESISKAARSHDRMIYY
YFGSKEQLFVEVLETIYTQFNEAESKLDLDLDDPVHGLEQMVEFVWQYYLDHPEFVTLLS
SENLHQGKHAKKSLKLKEISGYAISVVQKLLDAGQAQQVFRSDVKARDVYLMIASLGYFY
NANQYTLGAFLGEPLMDKASLDHWREVIKDTVLRAVRSSLPAQAGATALTVALNEAGQNS
EA