Protein Info for BPHYT_RS19925 in Burkholderia phytofirmans PsJN

Annotation: peptidase C39

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1018 transmembrane" amino acids 128 to 148 (21 residues), see Phobius details amino acids 460 to 482 (23 residues), see Phobius details amino acids 496 to 521 (26 residues), see Phobius details amino acids 570 to 594 (25 residues), see Phobius details amino acids 600 to 618 (19 residues), see Phobius details amino acids 678 to 702 (25 residues), see Phobius details amino acids 715 to 740 (26 residues), see Phobius details PF00027: cNMP_binding" amino acids 38 to 122 (85 residues), 59 bits, see alignment E=7.6e-20 amino acids 169 to 256 (88 residues), 62.3 bits, see alignment E=7.1e-21 PF03412: Peptidase_C39" amino acids 306 to 431 (126 residues), 130.6 bits, see alignment E=7.1e-42 PF00664: ABC_membrane" amino acids 463 to 730 (268 residues), 157 bits, see alignment E=1.6e-49 PF00005: ABC_tran" amino acids 796 to 945 (150 residues), 114.9 bits, see alignment E=9.1e-37

Best Hits

KEGG orthology group: K06147, ATP-binding cassette, subfamily B, bacterial (inferred from 100% identity to bpy:Bphyt_4002)

Predicted SEED Role

"ABC-type bacteriocin/lantibiotic exporter, contains an N-terminal double-glycine peptidase domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B2TE67 at UniProt or InterPro

Protein Sequence (1018 amino acids)

>BPHYT_RS19925 peptidase C39 (Burkholderia phytofirmans PsJN)
MDAPQTAPSAAEFLTSVEIFSPFSRDEIERLAEYAQARFYSFGETVCSAGETADGLYVIR
SGSVRIFSEEHGKETSLGVRKSGEIFADIAMLRTYVHEASVRSSAKTELLFIPRAAIEPV
IAGNQAALAFVASYVAINSAGGFVAQLFDLRGKLNKAELEEYVRSVGVKRVAAGKEILKQ
DGREDRRLYVVRHGEVRIVRHEEGHDYTLATLGEGEIFGEKACLMRQEQMASVVATTDTR
LLVIPERTVHFILERNPKLREVLDERIRYGDRELQRQKRVEQRRKLPLMLDLQSKPEFGE
KVIKRFALVEQAEEMDCGAACLAMVCRHYSIPMTLGKLRELANVTTQGATLDSLARAGES
LGFTARGVQCTFDSLRGFDLPFIVHWEGYHYVVVYGLSKEYVWVADPAVGFKKMTVEDFE
RGWSGTCLLFTGGPHLLQMSAARSPWIRFVGYLKPYKKILGHLFLATFVIQVLGVIPPLI
IQNILDGVIVHQNVSLLHLLIGGLIISNVFSQLMSSIRAYLANFMVRNMDFAMMSQFFKH
TMSLPFSFFAKRKTGDIFARFQENQTIRAFLTESTVTTALNLLMVFIYFTIMFVYNVKMT
LVLIAFVIPIMALTAIATPKIKGYAREVFTASTESKSFLMEALAGVETIKGMGIERPVRL
RWEKKYAKALEVQYRAHAFNILVGLGSQLLNSATTIAILWVGANLVLAREMTIGQLIAFN
AFMGSVLGPLMGLVGLWSMLNDAGVAMERLGDVLDIEPEQKPQDLPSRVMLPELQGEISL
SGVYFRYGENDSAYVLENISFDIKPGELVAIVGRSGSGKTTLAKLLVGFYTPTEGKMTID
GYDLGVVDKAYYRAQIGYVMQSNLLFSGTISENIASGDDAPDRRRIEEVAKMADAHGFIS
KMPLGYEQIVGERGIGLSGGQIQRLCIARALYHDPRLLVFDEATSALDSQSESNILGNMH
DILKGRTAVIIAHRLSTIMRADKILVLYEGAIVEQGRHDELIQRGGMYYQLVQKQLSA