Protein Info for BPHYT_RS18725 in Burkholderia phytofirmans PsJN

Annotation: LysR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 320 transmembrane" amino acids 223 to 243 (21 residues), see Phobius details PF00126: HTH_1" amino acids 3 to 62 (60 residues), 78.3 bits, see alignment E=3.3e-26 PF03466: LysR_substrate" amino acids 90 to 291 (202 residues), 149.6 bits, see alignment E=8.2e-48

Best Hits

Swiss-Prot: 41% identical to YWBI_BACSU: Uncharacterized HTH-type transcriptional regulator YwbI (ywbI) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 100% identity to bpy:Bphyt_3760)

Predicted SEED Role

"LysR family regulatory protein CidR" in subsystem Murein hydrolase regulation and cell death

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B2T6X4 at UniProt or InterPro

Protein Sequence (320 amino acids)

>BPHYT_RS18725 LysR family transcriptional regulator (Burkholderia phytofirmans PsJN)
MELRALRYFVEVVRQQSFTVAAEQMFVTQPTISKMVKSLEDEIGSPLLLRDGRQMVLTDA
GRIVYQRGQDVLAAHAQLQAELNDLDTLGRGQLTIGIPPMGGSLFTPAIAAFRQRYPKIE
LKLFEQGSRAIETALINGELELGGVLQPVDPENIDVLPMTRQLLWLVARTGSSWDDLHEV
PLAQLANEPFVFYGESLALNDVVLNACRTAGFAPTIVGRSGHWDFMAALVLAGVGIALLP
APYCRRLDPAQFTCRPVVEPEIPWEMAIGWRRNGYLSHAARAWLEVAREALPGQAADDFM
LGPGIGVTGITTPFPARPAE