Protein Info for BPHYT_RS17390 in Burkholderia phytofirmans PsJN

Annotation: anthranilate synthase subunit I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00564: anthranilate synthase component I
  • amino acids 25 to 486 (462 residues), 549.9 bits, E=2.6e-169
• PF04715: Anth_synt_I_N
  • amino acids 26 to 172 (147 residues), 123.6 bits, E=8.2e-40
• PF00425: Chorismate_bind
  • amino acids 221 to 478 (258 residues), 305.7 bits, E=3e-95

Best Hits

Swiss-Prot: 59% identical to TRPE_NEIMA: Anthranilate synthase component 1 (trpE) from Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

KEGG orthology group: K01657, anthranilate synthase component I [EC: 4.1.3.27] (inferred from 100% identity to bpy:Bphyt_3496)

MetaCyc: 55% identical to anthranilate synthase alpha subunit (Pseudomonas aeruginosa PAO1)
Anthranilate synthase. [EC: 4.1.3.27]

Predicted SEED Role

"Anthranilate synthase, aminase component (EC 4.1.3.27)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Tryptophan synthesis (EC 4.1.3.27)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• L-glutamate and L-glutamine biosynthesis (7/7 steps found)
• L-tryptophan biosynthesis (6/6 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (4/4 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• L-glutamine degradation I (1/1 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (3/4 steps found)
• superpathway of chorismate metabolism (42/59 steps found)
• 4-hydroxy-2(1H)-quinolone biosynthesis (3/5 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• acridone alkaloid biosynthesis (1/4 steps found)
• superpathway of quinolone and alkylquinolone biosynthesis (3/10 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.1.3.27

Use Curated BLAST to search for 4.1.3.27

Sequence Analysis Tools

See B2SZ01 at UniProt or InterPro

Protein Sequence (497 amino acids)

>BPHYT_RS17390 anthranilate synthase subunit I (Burkholderia phytofirmans PsJN)
MTELEFQSLANEGFNRIPLIAEALADLETPLSLYLKLAQSERNGANSFLLESVVGGERFG
RYSFIGLPARTLLRTRNGVSEVVRDGKVVETHEGDPLEFIQQFQGRFKVAQRPGLPRFAG
GLAGYFGYDAVRYIEKKLAHTAPKDDLNLPDIQLLLTEEVAVIDNLAGKLYLVVYSDPTQ
PEAYTKAKQRLRELRQRLRTTVQPPVTSASVRTETYREFAKDDYLAAVRKAKEYIAAGEL
MQVQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGDFHVVGASPEILVRQEKRGED
RIVTIRPLAGTRPRGNTPERDAELATELLNDPKEIAEHVMLIDLARNDVGRIAQIGSVVV
TDKMVIEKYSHVQHIVSSVEGKLKPGTTNFDVLRATFPAGTLSGAPKVRAMELIDELEPI
KRGLYGGAVGYLSFTGEMDLAITIRTGVIANGNLYVQAAAGVVADSVPESEWQETENKAR
AVLRAAEQVQDGLDSDF