Protein Info for BPHYT_RS16515 in Burkholderia phytofirmans PsJN

Annotation: 2-hydroxyacid dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 229 PF13560: HTH_31" amino acids 33 to 88 (56 residues), 37.2 bits, see alignment E=6e-13 PF13443: HTH_26" amino acids 35 to 88 (54 residues), 22.4 bits, see alignment E=2.3e-08 PF01381: HTH_3" amino acids 36 to 88 (53 residues), 44.7 bits, see alignment E=2.2e-15 PF07883: Cupin_2" amino acids 148 to 202 (55 residues), 41.3 bits, see alignment E=2.1e-14

Best Hits

KEGG orthology group: None (inferred from 100% identity to bpy:Bphyt_3325)

Predicted SEED Role

"Predicted transcriptional regulators"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B2SYI1 at UniProt or InterPro

Protein Sequence (229 amino acids)

>BPHYT_RS16515 2-hydroxyacid dehydrogenase (Burkholderia phytofirmans PsJN)
MHSPLALVRDPTADTDTSPRAAEPFDALEHLVGVNLARLRAERQLSLDALARASGVSRAM
LAQIESARSVPSIKVLCKVAAALKVSVAAFLRRHATNGFEHLPAERSSRVVSSNGRYSAR
PLYPDAEPTAAEFHELRIAPLHTEAGTRRAPGTTVNLVVSEGTLEVSVHDQRQLLATGDA
IVFDADQPHSLRNPGDTEARAFRVTLKAETPPRWDVPAHHEPAREVAPV