Protein Info for BPHYT_RS15690 in Burkholderia phytofirmans PsJN
Annotation: phosphopantothenate synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 55% identical to COABC_VIBCH: Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
KEGG orthology group: K13038, phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase [EC: 4.1.1.36 6.3.2.5] (inferred from 100% identity to bpy:Bphyt_3161)MetaCyc: 50% identical to fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase (Escherichia coli K-12 substr. MG1655)
Phosphopantothenate--cysteine ligase. [EC: 6.3.2.5]; Phosphopantothenoylcysteine decarboxylase. [EC: 6.3.2.5, 4.1.1.36]
Predicted SEED Role
"Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) / Phosphopantothenoylcysteine synthetase (EC 6.3.2.5)" in subsystem Coenzyme A Biosynthesis (EC 4.1.1.36, EC 6.3.2.5)
MetaCyc Pathways
- superpathway of coenzyme A biosynthesis I (bacteria) (9/9 steps found)
- superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
- coenzyme A biosynthesis I (bacteria) (4/4 steps found)
- coenzyme A biosynthesis II (eukaryotic) (4/4 steps found)
- coenzyme A biosynthesis III (archaea) (3/4 steps found)
- taurine biosynthesis II (1/4 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.1.36 or 6.3.2.5
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See B2T6I9 at UniProt or InterPro
Protein Sequence (404 amino acids)
>BPHYT_RS15690 phosphopantothenate synthase (Burkholderia phytofirmans PsJN) MATAELAGKHLVLGMTGGIACYKIAELTRLLTKAGATVQVVMTEAATQFITPVTMQALSG RPVYTSQWDGRVPNNMAHIDLSREADAIVIAPASTDFLAKLAHGMADDLLSTLCVARDCP LLVVPAMNRQMWQNPATQRNVAQVRADGIEVLGPDSGPQACGEVGDGRMLEAAATYEAIA SFFAPKILAGKRVLLTAGPTFEPLDPVRGITNRSSGKMGFALARAAQQAGAEVHLIAGPV ALETPWGVFRQDVQTAQQMHDAVMRSVADADIFIGVAAVADWRVDHASEHKIKKTAERAL PTFSFVENPDILASVAKLPHPPFTVGFAAESGDLEVHGEEKRVRKNVPLLIGNLGPLTFG LDDNEVILFEAGGATKLPRADKQTLARALIAEIAKRLPDTSLIR