Protein Info for BPHYT_RS14900 in Burkholderia phytofirmans PsJN

Annotation: prephenate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03807: F420_oxidored
  • amino acids 12 to 107 (96 residues), 24.8 bits, E=5.6e-09
• PF02153: PDH_N
  • amino acids 24 to 185 (162 residues), 107.9 bits, E=7.2e-35
• PF20463: PDH_C
  • amino acids 191 to 288 (98 residues), 91.6 bits, E=6.9e-30

Best Hits

KEGG orthology group: K04517, prephenate dehydrogenase [EC: 1.3.1.12] (inferred from 100% identity to bpy:Bphyt_3004)

Predicted SEED Role

"Cyclohexadienyl dehydrogenase (EC 1.3.1.12)(EC 1.3.1.43)" in subsystem Chorismate Synthesis or Phenylalanine and Tyrosine Branches from Chorismate (EC 1.3.1.12, EC 1.3.1.43)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• L-tyrosine biosynthesis I (3/3 steps found)
• 4-hydroxy-3-prenylbenzoate biosynthesis (3/4 steps found)
• L-tyrosine biosynthesis III (3/4 steps found)
• superpathway of chorismate metabolism (42/59 steps found)
• superpathway of novobiocin biosynthesis (6/19 steps found)

KEGG Metabolic Maps

• Novobiocin biosynthesis
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.1.12 or 1.3.1.43

Sequence Analysis Tools

See B2T631 at UniProt or InterPro

Protein Sequence (313 amino acids)

>BPHYT_RS14900 prephenate dehydrogenase (Burkholderia phytofirmans PsJN)
MTDVAAFSFNKLVIFGVGLIGGSLARALRERGEADGARKVIGVGRSSASTERALELGVID
GSASLNDDAALSEALKGADFVLLAAPVAQTQPLLERIAPFLDAATIVTDAGSTKSDVVAA
ARAALGARIGQFVPGHPIAGREASGVEAALPDLYVGRNVVLCPLPENAPADVERVAAMWR
ATGALVRDMAPEQHDRVLASVSHLPHVLSFALVEQILNSPDAALKFSFAAGGFRDFTRIA
ASSPEMWRDVCVANRVALLDELDAYTAVLARLRAAIEAADGAALEAVFARSRVARTEWQE
QRAAGVANSDASK