Protein Info for BPHYT_RS14600 in Burkholderia phytofirmans PsJN

Annotation: multidrug transporter MatE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 470 transmembrane" amino acids 59 to 83 (25 residues), see Phobius details amino acids 99 to 126 (28 residues), see Phobius details amino acids 144 to 163 (20 residues), see Phobius details amino acids 172 to 193 (22 residues), see Phobius details amino acids 202 to 226 (25 residues), see Phobius details amino acids 247 to 273 (27 residues), see Phobius details amino acids 282 to 304 (23 residues), see Phobius details amino acids 325 to 349 (25 residues), see Phobius details amino acids 362 to 381 (20 residues), see Phobius details amino acids 402 to 424 (23 residues), see Phobius details amino acids 430 to 448 (19 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 29 to 432 (404 residues), 241.1 bits, see alignment E=9.5e-76 PF01554: MatE" amino acids 29 to 188 (160 residues), 78.7 bits, see alignment E=2.1e-26 amino acids 253 to 419 (167 residues), 100.5 bits, see alignment E=4.2e-33

Best Hits

Swiss-Prot: 84% identical to NORM_BURMA: Probable multidrug resistance protein NorM (norM) from Burkholderia mallei (strain ATCC 23344)

KEGG orthology group: K03327, multidrug resistance protein, MATE family (inferred from 100% identity to bpy:Bphyt_2943)

Predicted SEED Role

"Multidrug and toxin extrusion (MATE) family efflux pump YdhE/NorM"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B2T5X3 at UniProt or InterPro

Protein Sequence (470 amino acids)

>BPHYT_RS14600 multidrug transporter MatE (Burkholderia phytofirmans PsJN)
MTQSGITRVAARPPTLTRHAADTARLAAPLAIAQLSQMAMGVTDTILLGSLGPDALAAGG
LGANLFFVVVTLLQGVLTSVSVSVSHARGAQDEGRVPHIYWTGLVLSVLLSVPAFFLLSF
ATPILLAFGEPALLAHNVGEYSAVLRWGSLGSLIGVGLMRSFLPAIGAAKRLLWVSLASV
GVNGFLNYGLIHGAYGLPRLGFLGSAAATSITVWLSALVLMALLHLRPRYRHFVVATRPN
VPLMGELFGIGWPVAITYGVESTLFLATGLMVGLLGESQLAAHQIALNVASVAFMVPLAI
GQAANVRVGFWSGAGQPLAARHAGFVALALGVAFMTLSGLVLIAAPHWIVGLYLHLDDPA
NAATVKLASSLLGVAAIFQIVDGMQTVGSGCLRGLKDTRVPMIAAAFGYWAIGFPTGYTL
AFHFGLGARGLWWGLAAGLASVALLMTLRFHKLSLRRVPAVSGASPVKPV