Protein Info for BPHYT_RS13965 in Burkholderia phytofirmans PsJN

Annotation: threonine aldolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01212: Beta_elim_lyase
  • amino acids 4 to 293 (290 residues), 248 bits, E=1.3e-77

Best Hits

Swiss-Prot: 64% identical to LTAE_PSEUN: Low specificity L-threonine aldolase (ltaE) from Pseudomonas sp. (strain NCIMB 10558)

KEGG orthology group: K01620, threonine aldolase [EC: 4.1.2.5] (inferred from 100% identity to bpy:Bphyt_2821)

Predicted SEED Role

"Low-specificity L-threonine aldolase (EC 4.1.2.48)" (EC 4.1.2.48)

MetaCyc Pathways

• superpathway of L-threonine metabolism (16/18 steps found)
• L-threonine degradation IV (2/2 steps found)
• glycine biosynthesis IV (1/1 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.1.2.48, 4.1.2.5

Use Curated BLAST to search for 4.1.2.48 or 4.1.2.5

Sequence Analysis Tools

See B2SZM7 at UniProt or InterPro

Protein Sequence (343 amino acids)

>BPHYT_RS13965 threonine aldolase (Burkholderia phytofirmans PsJN)
MQHFASDNYAGICPEALDALIAANNSGHEPAYGDDSWTNQVCDRLRELFQTDCEVFFVFN
GTAANSLALASLCQSYHSVICHELAHIETDECGGPEFFSNGSKLLTAPGIGGKLTPDAIE
AVVTRRADIHYPKPKVVTLTQSTEVGTVYSVEEVRAIAAIAKRRHLKVHMDGARFANAVA
ALDVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFDRALADDFAYRLKQAGQLASKMRF
ISAPWLGLLDNDVWLRNARHANAMAQLLQTRLQEIPGVSIMFPGESNAVFAQLPAQAAKA
MRARGWKFYEFIGAGGCRLMCAWDTQPETVERFAAEVRELCAA