Protein Info for BPHYT_RS13830 in Burkholderia phytofirmans PsJN

Annotation: acetyl-CoA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02316: propionate--CoA ligase
  • amino acids 3 to 629 (627 residues), 1095.5 bits, E=0
• PF16177: ACAS_N
  • amino acids 4 to 58 (55 residues), 89.8 bits, 1.2e-29
• PF00501: AMP-binding
  • amino acids 61 to 443 (383 residues), 247.4 bits, E=3.3e-77
• PF13193: AMP-binding_C
  • amino acids 511 to 594 (84 residues), 91.5 bits, E=7.7e-30

Best Hits

KEGG orthology group: K01908, propionyl-CoA synthetase [EC: 6.2.1.17] (inferred from 100% identity to bpy:Bphyt_2795)

Predicted SEED Role

"Propionate--CoA ligase (EC 6.2.1.17)" in subsystem Methylcitrate cycle or Propionate-CoA to Succinate Module (EC 6.2.1.17)

MetaCyc Pathways

• 2-methylcitrate cycle I (5/5 steps found)
• superpathway of coenzyme A biosynthesis II (plants) (8/10 steps found)
• 2-methylcitrate cycle II (5/6 steps found)
• β-alanine biosynthesis II (4/6 steps found)
• L-isoleucine biosynthesis IV (4/6 steps found)
• acrylate degradation II (1/3 steps found)

KEGG Metabolic Maps

• Propanoate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.17

Sequence Analysis Tools

See B2SZK1 at UniProt or InterPro

Protein Sequence (634 amino acids)

>BPHYT_RS13830 acetyl-CoA synthetase (Burkholderia phytofirmans PsJN)
MTSYRDFHRRSIEDPEAFWRDEARRIHWHTPFDTVLDRSNPPFARWFVGGRTNLCHNAVD
RHLAERAQQNALVYVSTETGIERRYTYAELYGEVNRMAAVMRSLDVKRGDVVLLYLPMIP
EALFAMLACARLGAIHSVVFGGFAAPNLAARIDDAKPVLIVTADAGARGGKVIDYTPLMD
EALARAQHKTPRVLLIDRQLAPERLNASYLVAYEPLREQFFDAHVPCEWLESNEPSYVLY
TSGTTGKPKGVQRDVGGYAVALAASMEHIFQGKAGDVMFTASDVGWVVGHSYIVYAPLIA
GLTTVMYEGTPIRPDGGIWWRLVAHHRINLMFTAPTALRVLKKQDPALLKQADLTSLRAL
FLAGEPLDEPTAAWIAGALDKPVIDNYWQTETGWPMLAIPRGVEALPTRLGSPGVPSAGF
NLTLRNELTGEPCPPGEKGVLTLDYPLPPGCMSTVWGDDKRFVSTYWSSIPNQQVYSTFD
WGVQDEDGYVTILGRTDDVINVAGHRLGTREIEEALSSHAAVAEVAVVGVTDPLKGQAAM
AFVVLRDAQAYADTKKRSKLDAELTATVDRQLGAIARPSRVVVVPMLPKTRSGKLLRRAI
AALAEGREPGDLPTIEDPAALQQVREALDDGAGK