Protein Info for BPHYT_RS12785 in Burkholderia phytofirmans PsJN

Annotation: Rrf2 family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 176 TIGR00738: Rrf2 family protein" amino acids 1 to 135 (135 residues), 144.4 bits, see alignment E=1.9e-46 TIGR02010: iron-sulfur cluster assembly transcription factor IscR" amino acids 1 to 138 (138 residues), 216.9 bits, see alignment E=7.5e-69 PF02082: Rrf2" amino acids 3 to 135 (133 residues), 141.1 bits, see alignment E=1.2e-45

Best Hits

Swiss-Prot: 56% identical to Y1593_NEIMA: Putative HTH-type transcriptional regulator NMA1593 (NMA1593) from Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

KEGG orthology group: K13643, Rrf2 family transcriptional regulator, iron-sulfur cluster assembly transcription factor (inferred from 97% identity to bge:BC1002_1892)

Predicted SEED Role

"Iron-sulfur cluster regulator IscR" in subsystem Rrf2 family transcriptional regulators

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B2T5M3 at UniProt or InterPro

Protein Sequence (176 amino acids)

>BPHYT_RS12785 Rrf2 family transcriptional regulator (Burkholderia phytofirmans PsJN)
MRLTTKGRFAVTAMIDLALRQEQGPVTLAGISQRQHISLSYLEQLFGKLRRHEIVESVRG
PGGGYNLARRAEDVTVADIIIAVDEPLDATQCGGKGSCEGTKQHDGHCMTHELWSTLNQK
MVEYLDSVSLKDLVDQQRSREGAPAVIRDRRNEAPAVEPVRVAPKGPNSVFNMAGS