Protein Info for BPHYT_RS12110 in Burkholderia phytofirmans PsJN

Annotation: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00243: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • amino acids 2 to 387 (386 residues), 514.8 bits, E=7.2e-159
• PF02670: DXP_reductoisom
  • amino acids 5 to 133 (129 residues), 157.5 bits, E=4.3e-50
• PF08436: DXP_redisom_C
  • amino acids 147 to 232 (86 residues), 132.9 bits, E=5.5e-43
• PF13288: DXPR_C
  • amino acids 264 to 380 (117 residues), 141.9 bits, E=1.6e-45

Best Hits

Swiss-Prot: 100% identical to DXR_PARPJ: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr) from Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)

KEGG orthology group: K00099, 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC: 1.1.1.267] (inferred from 100% identity to bpy:Bphyt_2449)

MetaCyc: 57% identical to 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli K-12 substr. MG1655)
1-deoxy-D-xylulose-5-phosphate reductoisomerase. [EC: 1.1.1.267]

Predicted SEED Role

"1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267)" in subsystem Isoprenoid Biosynthesis or polyprenyl synthesis (EC 1.1.1.267)

MetaCyc Pathways

• methylerythritol phosphate pathway II (8/9 steps found)
• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (10/12 steps found)
• taxadiene biosynthesis (engineered) (10/13 steps found)
• methylerythritol phosphate pathway I (7/9 steps found)
• isoprene biosynthesis I (7/10 steps found)
• superpathway of ergosterol biosynthesis II (11/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.267

Sequence Analysis Tools

See B2T5I8 at UniProt or InterPro

Protein Sequence (401 amino acids)

>BPHYT_RS12110 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Burkholderia phytofirmans PsJN)
MQKRLTLLGSTGSIGDSTLDVVARHPERFSVYALTAHRNGDKLVEQCLRFQPEVAVVGDA
DTAASVAAKLREAGCKTEITYGPQALVDVSKSDGCDTVVAAIVGAAGLAPSLAAARAGKR
ILLANKEALVMSGAIFMDAVRDNGAVLLPVDSEHNAIFQCLPREAALHGGVSKIILTASG
GPFRTREPATLVEVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNLPGERIE
VLIHPQSVIHSMVSYADGSVLAQLGNPDMRTPIAHALAFPDRVDSGVAQLDLLQVASLSF
EKPDYTRFPCLALAVKALAEGGLASAALNAANEIAVEAFLARQIGFMAIAQVVDAVLNAL
PNRSAHALEDVIEADAAARRAAAEFIARLPDGARRTERAVQ