Protein Info for BPHYT_RS11790 in Burkholderia phytofirmans PsJN

Annotation: fumarylacetoacetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 440 TIGR01266: fumarylacetoacetase" amino acids 15 to 438 (424 residues), 482.4 bits, see alignment E=5.7e-149 PF09298: FAA_hydrolase_N" amino acids 30 to 133 (104 residues), 88.2 bits, see alignment E=3.9e-29 PF01557: FAA_hydrolase" amino acids 166 to 415 (250 residues), 120.8 bits, see alignment E=7.2e-39

Best Hits

KEGG orthology group: K01555, fumarylacetoacetase [EC: 3.7.1.2] (inferred from 100% identity to bpy:Bphyt_2380)

Predicted SEED Role

"Fumarylacetoacetase (EC 3.7.1.2)" in subsystem Homogentisate pathway of aromatic compound degradation or Salicylate and gentisate catabolism (EC 3.7.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.7.1.2

Use Curated BLAST to search for 3.7.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B2T5B3 at UniProt or InterPro

Protein Sequence (440 amino acids)

>BPHYT_RS11790 fumarylacetoacetase (Burkholderia phytofirmans PsJN)
MQHILNQTHDPAARSWVESANAPTCDFPIQNLPFSVFRRRHSDEAFRGAVAIGDQVIDIA
AWASRAGLNGIAGEGARVCAQPVLNEFFSMGPSAWRAVRHALFAALHERAPSDDRAALEA
CLIPQSEVEYGLPAQIGDYTDFYTSIHHATNISKLLGLSGVGANFKSIPIAYHGRVSSIG
LSGQRFRRPAGQIMLPGEDAPIFSPSRKLDYELELGIYIGQGNAAGEPIALDQADSHVFG
LCLLNDWSARDIQAWEMQPLGPFLAKNFATTISPWIVTMEALAPFRLPLPRPHTDGKPLP
YLDSDRNSTTGAIDIQLEVCIETSRHQAGNLPAAQLSLTSFRHQYWSIAQMVAHHAAGGC
NLRAGDLLGSGTISGPGQSEAGALMELARNASEPVTLNTGEKRSYVEDGDAIILRGYCEK
AGFARIGFGESRGEVLPAKR