Protein Info for BPHYT_RS09515 in Burkholderia phytofirmans PsJN
Annotation: phosphoribosylformylglycinamidine synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Predicted SEED Role
"Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)" in subsystem De Novo Purine Biosynthesis (EC 6.3.5.3)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
- superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
- superpathway of purine nucleotides de novo biosynthesis II (24/26 steps found)
- superpathway of 5-aminoimidazole ribonucleotide biosynthesis (6/6 steps found)
- 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
- 5-aminoimidazole ribonucleotide biosynthesis II (5/5 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 6.3.5.3
Use Curated BLAST to search for 6.3.5.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See B2T414 at UniProt or InterPro
Protein Sequence (1361 amino acids)
>BPHYT_RS09515 phosphoribosylformylglycinamidine synthase (Burkholderia phytofirmans PsJN) MAHFSCFPGASALSDFRQTRLLETLTRIDPNITGVRGQYLHFVNAQTPLSAEDNAKIEAL MHYGDPLEETKERDTAETFLVVPRFGTVSPWASKATDIAHLCGLTQVRRIERGVEYTVTL KSGLLGGKKALSDEARAAVAAALHDRMTESVSSSRDHALHLFDELPAKPLQTVDILSNGR GALETANTELGLALADDEIDYLVDAFTKLGRNPTDVELMMFAQANSEHCRHKIFNADWTI DGEKQDISLFNMIRNTEKLNPRGTIVAYSDNSAIMAGGMAERWFPRTPADLGPSELPEHY RRSNELTHTLMKVETHNHPTAISPFPGAATGAGGEIRDEGATGRGARPKAGLAGFTVSNL ELPDGVEAWENARDAAQPLAQRNPDDKHEAYGRPDRIASPLQIMIDGPLGGAAFNNEFGR PNLGGYFRAYEQNVAGLVRGYHKPIMIAGGIGNISDQHTHKHDLPEGSLLIQIGGPGMRI GMGGGAASSMATGTNTAELDFDSVQRGNPEIERRAQEVINACWQLGEKNPILSIHDVGAG GLSNAFPEVVDGAGKGARFDLRKIQLEESGLSPREIWSNEAQERYVLAIAPADLPAFAAM CERERCPFAVIGTATAERQLKLIDSELNDDAAHQPVDMPMEVLLGKAPRMHRDVKRVERK LEPVDVTGLALSDVATSVLRHPTVASKSFLITIGDRSVGGTTARDQMVGPWQVPVADVAI TTMDYAGFTGEAMTMAERTPLAVIDAPASGRMAVGEAVTNIAAAPIASLDKLKLSANWMA ACGAAGEDAALYDTVKAIGMELCPALGISIPVGKDSLSMRTKWEDRGVAKEVVAPVSLII SAFAPVQDVRRHLTPQLRRTSDVGESVLIAIDLGRGKHRLGGSILAQVTQQVGDTVPDVD DPEDLKRFFAAIQALNQDGKLLAYHDRSDGGLWATVCEMAFAGHVGVSLNVDMLVLDPNH ESDYGDAKDWAKQTSGRREDRTIRALFNEELGAVVQVRASERDAVLAALREHGLSACSHV IGKINERDTIEIYRDAKKIYDAPRTELHRTWSEVSWRIARLRDNPACADAEYDALSDAAD PGISPILTFDPAEDVAAPFVGKSARPRVAILREQGVNSHLETAYAFDRAGFDAHDVHMSD LLAGRANLADFAGAVACGGFSYGDTLGAGEGWAKAIRFNAQLADMFAAFFGREDTFALGI CNGCQMMSSLASMIPGAEAWPKFTRNKSEKFEARFSLVEVQASPSLFFSGMEGSRIPVAI AHGEGYADFSQQGDASKVAVAMRYVDHRGQATEQYPFNPNGSPNGITSVTTPDGRFTVLM PHTERVHRAVQMSWHPEGWGEGATDASPWLRVFQNARRWLG