Protein Info for BPHYT_RS07235 in Burkholderia phytofirmans PsJN
Annotation: 2-hydroxymuconic semialdehyde dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 64% identical to AMNC_PSESP: 2-aminomuconic 6-semialdehyde dehydrogenase (amnC) from Pseudomonas sp.
KEGG orthology group: K10217, aminomuconate-semialdehyde dehydrogenase [EC: 1.2.1.32] (inferred from 100% identity to bpy:Bphyt_1465)MetaCyc: 71% identical to 2-aminomuconate 6-semialdehyde dehydrogenase (Pseudomonas fluorescens KU-7)
Aminomuconate-semialdehyde dehydrogenase. [EC: 1.2.1.32]
Predicted SEED Role
"2-aminomuconate semialdehyde dehydrogenase (EC 1.2.1.32)" (EC 1.2.1.32)
MetaCyc Pathways
- L-tryptophan degradation IX (11/12 steps found)
- L-tryptophan degradation XII (Geobacillus) (11/12 steps found)
- 2-nitrobenzoate degradation I (7/7 steps found)
- 2-amino-3-carboxymuconate semialdehyde degradation to 2-hydroxypentadienoate (4/4 steps found)
- 2-aminophenol degradation (3/4 steps found)
- 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA (3/5 steps found)
- L-tryptophan degradation III (eukaryotic) (10/15 steps found)
- 4-chloronitrobenzene degradation (3/9 steps found)
- 4-nitrotoluene degradation II (3/9 steps found)
- L-tryptophan degradation XI (mammalian, via kynurenine) (11/23 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.32
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See B2T2R9 at UniProt or InterPro
Protein Sequence (496 amino acids)
>BPHYT_RS07235 2-hydroxymuconic semialdehyde dehydrogenase (Burkholderia phytofirmans PsJN) MTFTPAAAQRAQPLLRHYVDGEFIATATTFPNLSPVDGSVLAQVCEADAETVDAAVRAAA AAQRAGWRNTTPAQRADWLHKIADGIQARFDEFVAAEVADTGRPLEQARKLDIARGIANF RTFGDLIRTANSEFFETHAADGSELINYVTRKPLGVIGIISPWNLPLLLFTWKVAPALAM GNCVVAKPSEETPGSATLLAEVMHDIGLPPGVFNLVHGHGPNAAGEFLTRHPDISAITFT GESRTGSTIMKTVADGVKEISFELGGKNAAVVFADADFDAAVAGVLKSSFTNAGQVCLCS ERVYVERSIFERFVAALKEKTEALRVGAPHDPETTMGPLISRGHREKVLSYFRLAVEEGA TVVTGGHVPQFGDERDQGAFVMPTIWTGLADDARCVKEEIFGPVCHIAPFDTEDEVIGRV NDSAYGLAASIWTTQLARGHRVARRIETGIVWVNAWFVRDLRTPFGGAKLSGIGREGGRH SLDFYSELTNICVRIA