Protein Info for BPHYT_RS04900 in Burkholderia phytofirmans PsJN

Annotation: cobyric acid synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 486 PF13500: AAA_26" amino acids 1 to 226 (226 residues), 64 bits, see alignment E=2.7e-21 PF01656: CbiA" amino acids 1 to 227 (227 residues), 79.2 bits, see alignment E=4.1e-26 TIGR00313: cobyric acid synthase CobQ" amino acids 1 to 479 (479 residues), 454.3 bits, see alignment E=2.6e-140 PF07685: GATase_3" amino acids 250 to 437 (188 residues), 196.5 bits, see alignment E=5.5e-62

Best Hits

Swiss-Prot: 100% identical to COBQ_PARPJ: Cobyric acid synthase (cobQ) from Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)

KEGG orthology group: K02232, adenosylcobyric acid synthase [EC: 6.3.5.10] (inferred from 100% identity to bpy:Bphyt_1005)

Predicted SEED Role

"Cobyric acid synthase (EC 6.3.5.10)" (EC 6.3.5.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B2T167 at UniProt or InterPro

Protein Sequence (486 amino acids)

>BPHYT_RS04900 cobyric acid synthase (Burkholderia phytofirmans PsJN)
MIQGTTSDAGKSTLVAGLCRLARRAGVRVAPFKPQNMALNSAVTVDGGEIGRAQALQAIA
AGIAAHTDLNPVLLKPTSDRGAQVIIHGKARMNLDARAYHDYKPVAFEAVLESYARLQAA
YETIFVEGAGSPAEINLRDRDIANMGFAEAVDCPVVLVADIDRGGVFAHLTGTLACLSAS
EQSRVRGFIINRFRGDVSLLKPGLDWLEAKTGKPVLGVVPYLHGLTLDAEDMLPPELRAA
HDGGAARMLRVVVPVLPHISNHTDFDALRAHPQVDFEYVRSGTPVPPADLIILPGSKNVP
GDLASLRAQGWDAVLQKHLRYGGRVIGICGGMQMLGREVADPHGVEGAPGTSAGLGWLDY
STVLTRDKTLKNVTGHLALPGSPEVAGYEIHMGETHGPALDTPALRLGDAQAAHPDGAIS
ADGQILATYVHGLFDTPAACAALLAWAGLSDAEEIDYPALREASLERLADTLAEHLDLPK
LFAAIG