Protein Info for BBR_RS20125 in Bifidobacterium breve UCC2003

Annotation: SIR2 family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02146: SIR2
  • amino acids 10 to 198 (189 residues), 143.1 bits, E=4.8e-46

Best Hits

KEGG orthology group: K12410, NAD-dependent deacetylase [EC: 3.5.1.-] (inferred from 96% identity to bln:Blon_2451)

Predicted SEED Role

"NAD-dependent protein deacetylase of SIR2 family" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate or Redox-dependent regulation of nucleus processes

KEGG Metabolic Maps

• 1,4-Dichlorobenzene degradation
• Caprolactam degradation
• Glutathione metabolism
• Lipopolysaccharide biosynthesis
• Lysine biosynthesis
• Nicotinate and nicotinamide metabolism
• Nucleotide sugars metabolism
• Sphingolipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.-

Use Curated BLAST to search for 3.5.1.-

Protein Sequence (251 amino acids)

>BBR_RS20125 SIR2 family protein (Bifidobacterium breve UCC2003)
MTKKIAVLTGAGISTSAGIPDFRGPDGVWTKHPDQMSVYDIDLFLRNKEDREYSWRWQKE
SPVWNAQSGAAHKALVKLEKAGMLTLLATQNFDALHEKAGNSSDVIVNLHGTIGTSHCMK
CHQEYDTADIMACLDEEPDPHCHRKLKYRGDMPCNGIINTDVVYFGEALPEGAMEKSYSL
ATKADELWVIGSTLEVYPAASIVPVAAQAGVPITIMNMGHTQYDHLASRLIHEDIAVALP
KLVNETIAENK