Protein Info for BBR_RS19550 in Bifidobacterium breve UCC2003
Annotation: PTS N-acetylglucosamine transporter subunit IIABC
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 41% identical to PTGA_BACHD: PTS system glucose-specific EIIA component (crr) from Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
KEGG orthology group: None (inferred from 67% identity to bbi:BBIF_0261)MetaCyc: 37% identical to Enzyme IIAGlc (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-168 [EC: 2.7.1.201]; TRANS-RXN-157 [EC: 2.7.1.201, 2.7.1.199]; RXN0-17 [EC: 2.7.1.201, 2.7.1.199, 2.7.1.192]
Predicted SEED Role
"PTS system, maltose and glucose-specific IIC component (EC 2.7.1.69) / PTS system, maltose and glucose-specific IIB component (EC 2.7.1.69) / PTS system, maltose and glucose-specific IIA component (EC 2.7.1.69)" in subsystem Maltose and Maltodextrin Utilization (EC 2.7.1.69)
MetaCyc Pathways
- glycolysis I (from glucose 6-phosphate) (10/13 steps found)
- superpathway of glycolysis and the Entner-Doudoroff pathway (12/17 steps found)
- superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (15/26 steps found)
KEGG Metabolic Maps
- Aminosugars metabolism
- Ascorbate and aldarate metabolism
- Fructose and mannose metabolism
- Galactose metabolism
- Glycolysis / Gluconeogenesis
- Nucleotide sugars metabolism
- Starch and sucrose metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.7.1.69
Use Curated BLAST to search for 2.7.1.192 or 2.7.1.199 or 2.7.1.201 or 2.7.1.69
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-positive bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (167 amino acids)
>BBR_RS19550 PTS N-acetylglucosamine transporter subunit IIABC (Bifidobacterium breve UCC2003) MTAAPAAAPKPAGTASTATVLAPVDGTIEPIDQVPDETFAEKLLGDGFAVIPKSDTIVAP VSGKVSTIAQAKHAVGITTDAGLEVLVHIGIDTVQLNGDPFTVKVTEGRQITAGDPIVEV DWNAVRAAGKATDVIVVFTNPALVDALAITAAGAVTSGSPVGTVTTK