Protein Info for BBR_RS19480 in Bifidobacterium breve UCC2003

Annotation: dihydrodipicolinate synthase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00701: DHDPS
  • amino acids 7 to 297 (291 residues), 229.6 bits, E=1.7e-72

Best Hits

Swiss-Prot: 36% identical to YAGE_ECOLI: Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE (yagE) from Escherichia coli (strain K12)

KEGG orthology group: K01714, dihydrodipicolinate synthase [EC: 4.2.1.52] (inferred from 100% identity to bll:BLJ_1832)

MetaCyc: 36% identical to CP4-6 prophage; putative 2-dehydro-3-deoxygluconate aldolase (Escherichia coli K-12 substr. MG1655)
DHDOGALDOL-RXN [EC: 4.1.2.51]; 2-dehydro-3-deoxy-D-pentonate aldolase. [EC: 4.1.2.51, 4.1.2.28]

Predicted SEED Role

"4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)" (EC 4.3.3.7)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• L-lysine biosynthesis III (6/7 steps found)
• L-lysine biosynthesis VI (6/7 steps found)
• dipicolinate biosynthesis (3/4 steps found)
• Entner-Doudoroff pathway II (non-phosphorylative) (6/9 steps found)
• L-lysine biosynthesis II (6/9 steps found)
• D-xylose degradation to ethylene glycol (engineered) (1/4 steps found)
• D-xylose degradation IV (1/7 steps found)
• superpathway of pentose and pentitol degradation (4/42 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis
• Pentose and glucuronate interconversions

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.52, 4.3.3.7

Use Curated BLAST to search for 4.1.2.28 or 4.1.2.51 or 4.2.1.52 or 4.3.3.7

Protein Sequence (297 amino acids)

>BBR_RS19480 dihydrodipicolinate synthase family protein (Bifidobacterium breve UCC2003)
MTSSAEFSGIICPSITITKDDGDIDYERWGQHLDHLIEAGINGVLVFGSIGEFYAFPLDV
KKQAVDFVAKHVAGRIKVFAGVGDTNLNNVIDFARAVEASGVDALVVVSPYYFGPTAGGA
KAYFGAVAEATNLPVILYNFPPRTGSDLTPELVAELAAAHPNIVGIKDTVDTISHTRKVI
RAVKAVNPRFAVFSGFDEYYLVNRVSGGDGVICGMTNVEPETFVTLHRAYEAGDYGTAIE
AAERISHLMALYDQTDLFISAIKGAVKAKGLNISTLIREPAVQLTAQQYEAIKAILK