Protein Info for BBR_RS19375 in Bifidobacterium breve UCC2003

Annotation: acyl-CoA carboxylase subunit beta

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01039: Carboxyl_trans
  • amino acids 51 to 537 (487 residues), 568.8 bits, E=9.6e-175

Best Hits

KEGG orthology group: None (inferred from 98% identity to blf:BLIF_1804)

MetaCyc: 48% identical to acyl CoA carboxylase carboxyltransferase subunit (Metallosphaera sedula)
Propionyl-CoA carboxylase. [EC: 6.4.1.3]; Biotin carboxylase. [EC: 6.4.1.3, 6.3.4.14]; RXN0-5055 [EC: 6.4.1.3, 6.3.4.14, 2.1.3.15]

Predicted SEED Role

"Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) / Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2); Propionyl-CoA carboxylase beta chain (EC 6.4.1.3)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.4.1.2, EC 6.4.1.3)

MetaCyc Pathways

• biotin-carboxyl carrier protein assembly (4/4 steps found)
• superpathway of fatty acid biosynthesis initiation (4/5 steps found)
• fatty acid biosynthesis initiation (type II) (2/3 steps found)
• fatty acid biosynthesis initiation (type I) (1/3 steps found)
• propanoyl CoA degradation I (1/3 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (10/16 steps found)
• superpathway of fatty acid biosynthesis II (plant) (29/43 steps found)
• 2-oxobutanoate degradation I (1/4 steps found)
• superpathway of fatty acids biosynthesis (E. coli) (35/53 steps found)
• candicidin biosynthesis (1/6 steps found)
• jadomycin biosynthesis (3/9 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (2/10 steps found)
• 3-hydroxypropanoate cycle (4/13 steps found)
• superpathway of candicidin biosynthesis (2/11 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (6/17 steps found)
• glyoxylate assimilation (3/13 steps found)
• superpathway of L-methionine salvage and degradation (5/16 steps found)
• methylaspartate cycle (6/19 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (4/18 steps found)
• superpathway of the 3-hydroxypropanoate cycle (4/18 steps found)
• mycolate biosynthesis (17/205 steps found)
• superpathway of mycolate biosynthesis (18/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis
• Propanoate metabolism
• Pyruvate metabolism
• Tetracycline biosynthesis
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 6.3.4.14

Use Curated BLAST to search for 2.1.3.15 or 6.3.4.14 or 6.4.1.2 or 6.4.1.3

Protein Sequence (540 amino acids)

>BBR_RS19375 acyl-CoA carboxylase subunit beta (Bifidobacterium breve UCC2003)
MTDIMDPPAVNAVTAASATNASQPPAHQPLRTAVVKAAELARVAEERARDKQHAKGKKTA
RERLDLLFDTGTFEEIGRFQGGNIAGGNAGAAVITGFGQVYGRKVAVYAQDFSVKGGTLG
TAEGEKICRLMDMAIDLKVPIVAIVDSGGARIQEGVAALTQYGRIFRKTCEASGFVPQLS
LILGPCAGGAVYCPALTDLIIMTRENSNMFVTGPDVVKASTGETISMADLGGGEVHNRVS
GVAHYLGEDESDAIDYARTVLAYLPSNSESKPPVYAYAATRAERETAKRLATIVPANERQ
PYDMLEVIRCIVDYGEFVQVQELFGASALVGFACIDGKPVGIVANQPNVLAGILDVDSSE
KVARFVRLCDAFNLPVVTLVDVPGYKPGSDQEHAGIIRRGAKVIYAYANAQVPMVTVVLR
KAFGGAYIVMGSKAIGADLNFAWPSSQIAVLGAAGAVNIIHRHDLAKAKASGQDVDALRA
KYIKEYETSTVNANLSLEIGQIDGMIDPEQTREVIVESLATLATKRRIKRTTKHHGNQPL