Protein Info for BBR_RS19370 in Bifidobacterium breve UCC2003
Annotation: type I polyketide synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Predicted SEED Role
"[Acyl-carrier-protein] acetyl transferase of FASI (EC 2.3.1.38) / Enoyl-[acyl-carrier-protein] reductase of FASI (EC 1.3.1.9) / 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase of FASI (EC 4.2.1.61) / [Acyl-carrier-protein] malonyl transferase of FASI (EC 2.3.1.39) / [Acyl-carrier-protein] palmitoyl transferase of FASI (EC 2.3.1.-) / Acyl carrier protein of FASI / 3-oxoacyl-[acyl-carrier-protein] reductase of FASI (EC 1.1.1.100) / 3-oxoacyl-[acyl-carrier-protein] synthase of FASI (EC 2.3.1.41)" (EC 1.1.1.100, EC 1.3.1.9, EC 2.3.1.-, EC 2.3.1.38, EC 2.3.1.39, EC 2.3.1.41, EC 4.2.1.61)
MetaCyc Pathways
- superpathway of fatty acid biosynthesis initiation (4/5 steps found)
- fatty acid biosynthesis initiation (mitochondria) (3/4 steps found)
- gondoate biosynthesis (anaerobic) (3/4 steps found)
- fatty acid biosynthesis initiation (type II) (2/3 steps found)
- palmitate biosynthesis II (type II fatty acid synthase) (22/31 steps found)
- stearate biosynthesis II (bacteria and plants) (4/6 steps found)
- palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) (6/9 steps found)
- fatty acid elongation -- saturated (3/5 steps found)
- oleate biosynthesis IV (anaerobic) (9/14 steps found)
- (5Z)-dodecenoate biosynthesis I (3/6 steps found)
- (5Z)-dodecenoate biosynthesis II (3/6 steps found)
- stearate biosynthesis IV (3/6 steps found)
- superpathway of fatty acid biosynthesis I (E. coli) (10/16 steps found)
- 8-amino-7-oxononanoate biosynthesis IV (2/5 steps found)
- cis-vaccenate biosynthesis (2/5 steps found)
- superpathway of fatty acid biosynthesis II (plant) (29/43 steps found)
- fatty acid biosynthesis initiation (plant mitochondria) (1/4 steps found)
- 8-amino-7-oxononanoate biosynthesis I (6/11 steps found)
- octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) (6/12 steps found)
- superpathway of fatty acids biosynthesis (E. coli) (35/53 steps found)
- petroselinate biosynthesis (1/6 steps found)
- superpathway of unsaturated fatty acids biosynthesis (E. coli) (11/20 steps found)
- 2-allylmalonyl-CoA biosynthesis (1/8 steps found)
- biotin biosynthesis I (6/15 steps found)
- palmitate biosynthesis III (14/29 steps found)
- mycobactin biosynthesis (1/11 steps found)
- tetradecanoate biosynthesis (mitochondria) (11/25 steps found)
- pederin biosynthesis (2/14 steps found)
- streptorubin B biosynthesis (14/34 steps found)
- anteiso-branched-chain fatty acid biosynthesis (13/34 steps found)
- even iso-branched-chain fatty acid biosynthesis (13/34 steps found)
- odd iso-branched-chain fatty acid biosynthesis (13/34 steps found)
- bryostatin biosynthesis (2/19 steps found)
- mupirocin biosynthesis (1/26 steps found)
- corallopyronin A biosynthesis (2/30 steps found)
- mycolate biosynthesis (17/205 steps found)
- superpathway of mycolate biosynthesis (18/239 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- Alkaloid biosynthesis I
- Alkaloid biosynthesis II
- Anthocyanin biosynthesis
- Benzoate degradation via CoA ligation
- Biosynthesis of terpenoids and steroids
- Biosynthesis of type II polyketide backbone
- Biosynthesis of unsaturated fatty acids
- Butanoate metabolism
- Carotenoid biosynthesis - General
- Diterpenoid biosynthesis
- Ether lipid metabolism
- Ethylbenzene degradation
- Fatty acid biosynthesis
- Glycerophospholipid metabolism
- Glycosphingolipid biosynthesis - ganglio series
- Histidine metabolism
- Limonene and pinene degradation
- Lipopolysaccharide biosynthesis
- Lysine degradation
- Phenylalanine metabolism
- Tyrosine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.100, 2.3.1.-
Use Curated BLAST to search for 1.1.1.100 or 1.3.1.9 or 2.3.1.- or 2.3.1.38 or 2.3.1.39 or 2.3.1.41 or 4.2.1.61
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-positive bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (3160 amino acids)
>BBR_RS19370 type I polyketide synthase (Bifidobacterium breve UCC2003) MSTFFLNRLTTEPHALAFAGQSTPWPVTLADQTTDPSLDEDLRGHVAAANRLLAPAAADL LATTGRPVDLFGFTPNPARLSAAADATASVEGVALTQLGALLDLEHLGYSVAAAKPVAVL GHSQGVLAVHMTRAIEAAGSIEAAGKTLDEILAVAALIGAAGTRRVRELGLNPKYGEASP MLSVKGATREQVEALVKRVNNARGPISIAVTNSDNHHVLSGHPEDLAALALETEREHQHQ AKLREQKLHGGTVFNPTLEYLEVTLPFHSPLMAEAVEQTVSWAGACGFDQDRTRALAEEV LLNHVDWNARVKALFNAADPAKLWIVDLGPGNTLGKLIGNVVQGTGIGVVEATTLAERSA LSTLESEPERTQNWKALAPRVIETPAGAKLVTKFSKLTGKPPVLLPGMTPTTVEPEIVAA AANAGYWAELAGGGQVTAEVFDRHIAALEDELEEGRTVEFNAMFMDRYLWNLQFGSSRIV PKKRASGAPIDGVVVSAGIPELDEAVELIKNLQADGLPYVSFKPGTVDQIRQVVRIAKAV APTTIMIQVEGGEAGGHHSWEALDDLLAATYAEVRACDNLVLVAGGGIGTPERAADYISG QWAHAYGLPDMPVDGVLIGTAAMTAKEAHTSPEVKQMLVKTPGIPADAKSDDVFAPQAAH WVPSGKSVGGMSSGLSHLHADIYELENDSAECGRLLVRVMKHPEELDSRRKEIIEALNKT AKPYFGDLASMTYLEWAQRFAELAFPWADPTYADRFQHLLQRIEARANDTDSGEFTSKLF AADGVSADEAAAAGLLTRDGILADPAPALEKLALAYPQTAELKVVPADVAWFPVLVREYP KPMPFVPVIDNDLLRWWGQDQLWQSEDQRYSADSVRAIPGPISVAGITTVDEPIADILGR FENAAIERVKAEQNASESNDFAALGEAVSAEDFIRKSPNISWVGHIADNPAYGTALGDQY YEIRAFDAAAGKYDLDIHLDTYWDNDPDGGTSKHAVRDIVIPLIVEGTEPGRVPVVDRER LIPDVYAMLAATAGIGNTAITGDKLTAMPTLSVPSDEGAVTANAVTEGETAQNRPFGTAT ATYTLSANLGFDHEAATGAALPSTLQPSRIAPDALVGPAWPAIYTALGSVYVKGYPVIEG LLNAVHLDHLIELEVNEEDLLKHTGETITLKSWAEDYFESASGRVVTIHVTHTAADGTLL ARETERFAIRGRVYSDALPADAPEFGDAEHAEVAPTPRRLLRRVKVVAPHDMTAFARTSG DFNPIHTSTRGARISGLAAPLVHGMWLSATAQHAVQALDEKGAHYEIAGWTYNMYGMVQL DDTVEISVERVGKVRHGGMTLEVTCRIDGQLVSRGTALVRAPRAAFVYPGQGIQKQGMVL DERAKSAAARDVWERADKLTRAKLGFSILGLVRDNPKELTANGVTYRHPEGLLNLTQFTQ VALATVAFAQTARLREAGADIWPAYFAGHSLGEYNALSAFADVIPLETVLELVFHRGSTM HHLIERDAQGRSNYRMGALRPNQFGVDDAHVKEYVESVAKASGEFLEIVNYNLAGQQYAI AGTIAGLKALKADSARRVAAFGGKPAFMLVPGIDVPFHSTLLRKGVPEFRDKLDALLPAY IDYRGRLVDRYIPNLVASPFEMTKEFAAKILEVVPSERIKAALDDPAVWDSYAADDQKLG RLLLTELLSWQFASPVRWIETQALLFGKREQGGLGVEEYVEVGLGNAPTLANLGAKTLRL PEFAGNDTVVYNVGRDEGRVYMTDTDSLVPDDEPEETAAPVETAPAGGSAVAKLGSSAAA DAAPAAAAAPAPAAPVSAAPAGAPSGAAVADLPFKASDGIGVLMAYAAKVRLDQIGSNDT TDTLTNGVSSRRNQLLMDISSELGVASVDGAAEATLDKLAQIVNKAAPNYKPFGAVLSEA LRDRLRSLFGAAGVKQQYIRDRVANVWQLGEGWVASVLAALLLDTREGSSSRGGDLAKLP TAAVQNKPEADKLIDAAVEVVAQLKGVAVALPSAGGAAGGAVVDSAALDAFAEKVTGSNG VLAATARFVLNELGVAAPAPEESEDENAAVVAAVEAELGSDWPKQVAPRFDANKAILFDD RWASAREDLARAYYDNDPAALNGSFIGLGKTIAAEAQWFADKSNNDELKAAFQKAASEAL ESVTSDKNASRYANDIAIVTGVSPNSIAAQVVEGLLAGGATVVATSHSFKPSIKAWAKQA YREHATGNAKLWLVPANLSSYRDVDALVDWVGHEQKKTSGATTTILKPAWEPTLFFPFAA PPVHGTLADSGDLFESQARLMLWGVERAIAGFSHIGADANVQHKLHVVLPGSPNRGVFGG DGAYGEVKSAFDAIVNRARAEKVWSSRVTFAHPKIGWVRGTGLMGGNDPLVAVVERHGIH TYSTAQIAAKLLDLCTAESREQALKAPLNVDLTGGLGSEPIDIKALRTEAMADAEKEASS EKAAIEGEKPEGGAAGSTLKALPTPIVTKQAPVDLADWQNVTARPEDEIVIVSVGELGPW GSGRTRAQAELGIHSDGTVDLSAGAVLELAWNMGLLTWADSPKPGWYDTDGNLVPEEDIA ERYHDEVVARSGIRPFEEGMGDDYKDGADEEEAEVFLDHDVTFSVPTREVAAEYVKLDEA HTTIAPDEESGEWNVTRHAGSMIRVPRRATMTRTVGGQFPKGFDPTRWGIPASMVGDVDK IALWNIVTTVDAYLGAGFTPAEILESIHPSLVASTQGTGFGGMMSMRKLYLDRFLNHEIP TDILQEALPNVVAAHVMQSYIGGYGNMIQPVSACATAAVSLEEGVDKIALGKADFVVTGA IDDIGVESVIGFGNMNATANSEEMYGKGIDARFFSRANDRRRGGFLESQGGGTILVTRGD IAEKLGLPVAAVVGFIHSYADGAHTSIPAPGLGALAAGMGGEDSKLVRDLAKLGVSADDI AVVSKHDTSTNANDPNESELHNTLAHAIGRTDGNPLFVISQKTLTGHAKGGACIFQVNGL TQLFKSGVIPANVSLDCVDPKLQRDDHMVWVRKPLRIGGGEDEFGRETAGRPVKAGLATS LGFGHVSGFVALVHPGAFEAAVAKADGEAALEAWRERANARLVAGQRHLEEGMMGRAALY EPIDNRRFHEDHRGYDHHEVEKAMLLNPDARLGADGYYEA