Protein Info for BBR_RS19250 in Bifidobacterium breve UCC2003

Annotation: aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 445 PF03051: Peptidase_C1_2" amino acids 7 to 442 (436 residues), 471.6 bits, see alignment E=2.4e-145 PF00112: Peptidase_C1" amino acids 357 to 404 (48 residues), 21.3 bits, see alignment 2.5e-08

Best Hits

Swiss-Prot: 40% identical to PEPC_LACDL: Aminopeptidase C (pepC) from Lactobacillus delbrueckii subsp. lactis

KEGG orthology group: K01372, bleomycin hydrolase [EC: 3.4.22.40] (inferred from 98% identity to blf:BLIF_0272)

Predicted SEED Role

"Aminopeptidase C (EC 3.4.22.40)" in subsystem Protein degradation (EC 3.4.22.40)

Isozymes

Compare fitness of predicted isozymes for: 3.4.22.40

Use Curated BLAST to search for 3.4.22.40

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (445 amino acids)

>BBR_RS19250 aminopeptidase (Bifidobacterium breve UCC2003)
MTEITKLSVEDLQSLRDSFTADETNRIAMNAVTAAGIDKVAKNYDRARLLQRRFSTIVDN
GEVTHQDRSGRCWLFSSLNVARFVAKKNMDLEHFEFSQNYAMYYDKLERVNYFLKDMACL
VEAGEPEDSRLVQHLLREVMGDGGQWTMAMNVYKKYGAVPKDLFPETESSKNTGPMNNKL
CELMRQAVAHMYENPENIDQIVKNATEAGHRILTIHLGEPPVSFDWEWTDKDDEFHRDGE
ITPVEFWKKYVGSADLESYVCLVDDPRKEHPKGRKIAIEHLGNVVGGDATEYLNVPNQFM
KDCVRRVLVEQGIPVWFGAECGPMMDREAGAWATDLFEYDRVYGVRFDLSKEQRVRFGNS
AMDHAMAFAGVDVADDGTTTRRWRVENSWGDKIADKGYFTMSDDWFTEYVYEVAVPKALL
PEEYQKALEEPAISLPAWDPMGALA