Protein Info for BBR_RS19000 in Bifidobacterium breve UCC2003

Annotation: 2-hydroxyacid dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 338 PF00389: 2-Hacid_dh" amino acids 32 to 335 (304 residues), 51.7 bits, see alignment E=1.1e-17 PF02826: 2-Hacid_dh_C" amino acids 129 to 304 (176 residues), 177.7 bits, see alignment E=2.3e-56 PF03446: NAD_binding_2" amino acids 166 to 273 (108 residues), 32.6 bits, see alignment E=1.2e-11

Best Hits

KEGG orthology group: None (inferred from 91% identity to blo:BL1568)

Predicted SEED Role

"Phosphoglycerate dehydrogenase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (338 amino acids)

>BBR_RS19000 2-hydroxyacid dehydrogenase (Bifidobacterium breve UCC2003)
MTEIYETQSERTDLPLVVMPAVLDAMIEPIKAQFPALHDVARVRMFEEFTSDEAVLAERL
KNADALLVGGYHISDDLLRTISEQGHVKCIVFCGTGVASYINLELARELKVRVCNAEHYG
DHAVAEHTFALLFELIRKVGQLDKDVKAGNWAWAGGDGLQLAGRRMGIIGLGGIGTTVAG
IARAFGMEVAAWNSHVPAEHFERSGSVPVDDLNELIETSDVISVHLPLNDATRGIVTAEN
LAHLQPGTMLINTARSEVIESGALFARLQEGDIPAALDVFDHEPLTVDDPICHVPGIVLT
PHVGWRTDGAFKELTRQMIACMNAYFAGEDYNVVVSEH